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Different views about the biomechanics of the knee joint and late
re construction of ligamentous injuries underline the obstacles
impeding the establishment of generally acceptable principles for
the treat ment of such lesions. As late as June 1976, HUGHSTON
emphasized in the Journal of Bone and Joint Surgery that in spite
of excellent anatomic studies, substantial uncertainty still
prevails in knee joint surgery. Even the signifi cance of the
anterior drawer sign for ruptures of the anterior cru ciate
ligament is interpreted quite diversely, as illustrated in a
comparison of HUGHSTON, GIRGIS, TORG, and SCHIECK, who give varying
opinions concerning the indication related to the age of the
patient or possible earlier joint damage as well as concerning the
prognosis for untreated knee joints. The question still remains as
to how often an intra-articular ligamentous replacement should be
carried out in addition to extra-articular techniques (0 'DONOGHUE,
SLOCUM, NICHOLAS, HUGHSTON). Lastly the question of synthetic
ligament replacement must be clarified. After basic research has
well advanced, clinical ex perience must be discussed. Statements
concerning the therapeutic value of diverse procedures based solely
on knowledge of the literature remain problematic. For this reason
a workshop was held at the University of Heidelberg in the
Orthopedic Clinic (Head: Prof. Dr. H. COTTA) in June 1977, with the
aim of bringing together representatives of the different leading
schools in a round table discussion to comment on still unsolved
ques tions."
Photodynamic therapy (PDT) is increasingly being used amongst
health practitioners in combating a variety of diseases. One common
strategy used during this light activated process is to induce the
accumulation of significant amounts of a photosensitising agent in
the diseased tissue. The naturally occurring amino acid
5-aminovulinic acid (ALA) is used to produce high levels of the
photosensitizer, Protoprophyin IX, in the therapy known as ALA-PDT.
Written by experts in the field Photodynamic therapy with ALA
outlines a variety of clinical approaches to the topic, outlining
current applications. These include the use of ALA-PDT and ALA-FD
(fluorescence diagnosis) in the areas of dermatology, urology,
brain, otorhinolaryngology, gynaecology and gastroenterology. Also
included is a chapter that comprehensively reviews the scientific
principles of ALA-PDT. Primarily aimed at a clinical audience
Photodynamic therapy with ALA should provide a comprehensive review
and useful insight into ALA-PDT.
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