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The volumes of this classic series, now referred to simply as
"Zechmeister" after its founder, Laszlo Zechmeister, have appeared
under the Springer Imprint ever since the series' inauguration in
1938. The series has featured contributions by seven Nobel
laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K.
Alder, O. Diels, P. Karrer, H. von Euler-Chelpin.
The volumes contain contributions on various topics related to the
origin, distribution, chemistry, synthesis, biochemistry, function
or use of various classes of naturally occurring substances ranging
from small molecules to biopolymers. Each contribution is written
by a recognized authority in the field and provides a comprehensive
and up-to-date review of the topic in question. Addressed to
biologists, technologists, and chemists alike, the series can be
used by the expert as a source of information and literature
citations and by the non-expert as a means of orientation in a
rapidly developing discipline.
The volumes of this classic series, now referred to simply as
"Zechmeister" after its founder, L. Zechmeister, have appeared
under the Springer Imprint ever since the series' inauguration in
1938. It is therefore not really surprising to find out that the
list of contributing authors, who were awarded a Nobel Prize, is
quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle,
Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul
Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with
Walter Norman Haworth and Adolf F.J. Butenandt serving as members
of the editorial board. The volumes contain contributions on
various topics related to the origin, distribution, chemistry,
synthesis, biochemistry, function or use of various classes of
naturally occurring substances ranging from small molecules to
biopolymers. Each contribution is written by a recognized authority
in his field and provides a comprehensive and up-to-date review of
the topic in question. Addressed to biologists, technologists and
chemists alike, the series can be used by the expert as a source of
information and literature citations and by the non-expert as a
means of orientation in a rapidly developing discipline.
The first three chapters of Vol. 3 of Bio-organic Marine Chemistry
deal with the chemistry and function of peptides. Chapter 1 by
Ireland and coworkers serves as an introduction to marine-derived
peptides. It is arranged phyletically and encompasses the entire
range from dipeptides to a compound with 95 amino acid residues.
Peptides involved in primary metabolism and hence belonging to the
realm of macromolecular biochemistry are excluded. However, it
might be mentioned in passing that the dividing line between large
and small molecule chemistry is continually becoming less distinct.
Not only are more compounds of intermediate size, from 1,000 to
10,000 dalton, being discovered, but instruments and techniques,
particularly in mass spectrometry and nuclear magnetic resonance
have been developed for their structural elucidation by what is
considered small molecule methodology. Two groups of peptides are
discussed in separate chapters. Biologists who have observed and
described the mating behavior of diverse species of marine
invertebrates have long surmised that a chemical mechanism might be
operating in many cases of individual as well as mass
fertilization. The chemical activators of sea urchin sperm prove to
be a series of peptides, whose structures and activity are
discussed by Suzuki.
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