This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities. Contributions from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning.

The present volume of reprints are what I consider to be my most interesting and influential papers on algebra and topology. To tie them together, and to place them in context, I have supplemented them by a series of brief essays sketching their historieal background (as I see it). In addition to these I have listed some subsequent papers by others which have further developed some of my key ideas. The papers on universal algebra, lattice theory, and general topology collected in the present volume concern ideas which have become familiar to all working mathematicians. It may be helpful to make them readily accessible in one volume. I have tried in the introduction to each part to state the most significant features of ea ch paper reprinted there, and to indieate later developments. The background that shaped and stimulated my early work on universal algebra, lattice theory, and topology may be of some interest. As a Harvard undergraduate in 1928-32, I was encouraged to do independent reading and to write an original thesis. My tutorial reading included de la Vallee-Poussin's beautiful Cours d'Analyse Infinitesimale, Hausdorff's Grundzuge der Mengenlehre, and Frechet's Espaces Abstraits. In addition, I discovered Caratheodory's 1912 paper "Vber das lineare Mass von Punktmengen" and Hausdorff's 1919 paper on "Dimension und Ausseres Mass," and derived much inspiration from them. A fragment of my thesis, analyzing axiom systems for separable metrizable spaces, was later published 2]. * This background led to the work summarized in Part IV."

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

The present volume of reprints are what I consider to be my most interesting and influential papers on algebra and topology. To tie them together, and to place them in context, I have supplemented them by a series of brief essays sketching their historieal background (as I see it). In addition to these I have listed some subsequent papers by others which have further developed some of my key ideas. The papers on universal algebra, lattice theory, and general topology collected in the present volume concern ideas which have become familiar to all working mathematicians. It may be helpful to make them readily accessible in one volume. I have tried in the introduction to each part to state the most significant features of ea ch paper reprinted there, and to indieate later developments. The background that shaped and stimulated my early work on universal algebra, lattice theory, and topology may be of some interest. As a Harvard undergraduate in 1928-32, I was encouraged to do independent reading and to write an original thesis. My tutorial reading included de la Vallee-Poussin's beautiful Cours d'Analyse Infinitesimale, Hausdorff's Grundzuge der Mengenlehre, and Frechet's Espaces Abstraits. In addition, I discovered Caratheodory's 1912 paper "Vber das lineare Mass von Punktmengen" and Hausdorff's 1919 paper on "Dimension und Ausseres Mass," and derived much inspiration from them. A fragment of my thesis, analyzing axiom systems for separable metrizable spaces, was later published 2]. * This background led to the work summarized in Part IV."