This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi cant role in this process, which is duly emphasized. Based on appro priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge."

This pathology atlas on CD-ROM consists of 22 CD-ROMS, each dedicated to one organ system (see list of titles). Three CD-ROMs have already been prepared, the others are scheduled to appear within the next two years. Each CD-ROM is basically an image database depicting the known lesions of a given organ system, a short description of the lesion as well as the international classification of the lesion. Three types of classification are available upon entering the programme: ICD-10, SNOMED, or ADICAP. The programm is in English or French clickable. The authors are soliciting pathologists from countries all over the world to help promote the series.