'Writing Worlds' represents the first systematic attempt to apply poststructuralist ideas to landscape representation. Landscape - city, countryside and wilderness - is explored through the discourse of economics, geopolitics and urban planning, travellers descriptions, propaganda maps, cartography and geometry, poetry and painting. The book aims to deconstruct geographical representation in order to explore the dynamics of power in the way we see the world.

Emphasizing state-of-the-art pharmacological and therapeutic approaches in controlling pathophysiological processes in the airways, Pharmacology and Therapeutics of Airway Disease reviews normal and abnormal physiological, biochemical and molecular aspects of the respiratory tract.Covering the basic mechanisms of inflammatory cell activation and pathophysiology in disease, therapeutic ways of controlling inflammation, reversing or preventing airflow obstruction, and symptomatic treatments of advanced disease. Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses: pathophysiology of respiratory tract diseases the methods of measuring airway and clinical responses the concepts upon which many treatments are used in COPD and asthma conditions the way in which these treatments work, and how new treatments can be discovered and tested in various patient groups state-of-the-art pharmacological and therapeutic approaches in controlling pathophysiological processes in the airways normal and abnormal physiological, biochemical and molecular aspects of the respiratory tract basic mechanisms of inflammatory cell activation and pathophysiology in disease therapeutic ways of controlling inflammation ways of reversing or preventing airflow obstruction, and symptomatic treatments of advanced disease

This excellent reference traces the construction and maintenance of the digital collections and services that have been available day in and day out to users worldwide for more than a decade. It examines applicable guidelines for any library looking to build and manage systems, conduct and evaluate projects, and scout new directions for mainstreaming and hybridizing the building of a digital library. Including contributions from seasoned experts in specializations such as staffing, collection development, and technology project management for digital libraries, Becoming a Digital Library discusses the techniques for finding and training the right people to build a digital library.

"This outstanding resource offers comprehensive presentations of the latest basic knowledge and the most advanced research on neuropeptides of the respiratory tract covering the structure, receptors, molecular biology, and function of each important neuropeptide and examining how they relate to disease. Demonstrates the utility of immunohistochemistry, autoradiography, molecular biology, smooth muscle contraction, and glandular secretion for the study of neural function both in vitro and in vivo "

The purpose of this book is to explore issues of geographical description from a poststructuralist sensibility. Focusing on landscape representation, the authors organize their discussion of geographical writings around the three themes of discourse, text and metaphor. Each theme is used as a potential entry point into understanding the shape and substance of particular kinds of geographical writings: the discourse of economics, geopolitics and urban planning, travellers' descriptions, propaganda maps, cartography and geometry, poetry and painting. Representation of the landscape - city, countryside or wilderness - are not mimetic, rather they are a product of the nature of the discourse in which the text is written. Though the landscape representations explored by the authors varies considerably - travellers' accounts of Niagara Falls to Turner's painting of Leeds - each is a written world within a discrete discourse. These essays all participate in the ongoing project of deconstructing geographical discourse to explore the dynamics of power in the representation of landscape. This book should be of interest to students and lecturers in geography, cultural studies and sociology.

Based on the author's well-established courses, Group Theory for the Standard Model of Particle Physics and Beyond explores the use of symmetries through descriptions of the techniques of Lie groups and Lie algebras. The text develops the models, theoretical framework, and mathematical tools to understand these symmetries.

After linking symmetries with conservation laws, the book works through the mathematics of angular momentum and extends operators and functions of classical mechanics to quantum mechanics. It then covers the mathematical framework for special relativity and the internal symmetries of the standard model of elementary particle physics. In the chapter on Noether's theorem, the author explains how Lagrangian formalism provides a natural framework for the quantum mechanical interpretation of symmetry principles. He then examines electromagnetic, weak, and strong interactions; spontaneous symmetry breaking; the elusive Higgs boson; and supersymmetry. He also introduces new techniques based on extending space?time into dimensions described by anticommuting coordinates.

Designed for graduate and advanced undergraduate students in physics, this text provides succinct yet complete coverage of the group theory of the symmetries of the standard model of elementary particle physics. It will help students understand current knowledge about the standard model as well as the physics that potentially lies beyond the standard model.

A visionary new horror novel in the style of Wells' creepiest and most enduring fictions - a future history following the descendants of the Island of Dr Moreau In H G Wells' The Island of Dr Moreau a shipwrecked traveller finds himself alone on an island ruled by a mad doctor and inhabited by creatures who are at once both beast and human. He escapes...but that is only the beginning of the story. The City of Dr Moreau is a sprawling history of the islanders, and an alternative vision of our own times. Spanning more than a century, criss-crossing across numerous places and many lives, we witness the growth of Moreau's legacy, from gothic experiments to an event which changes the world. From the wharves of Victorian London to a boarding house with an inhuman resident to an assassin on a twentieth-century train ordered to kill the one man who knows the truth, we follow secret skirmishes and hidden plots which emerge, eventually and violently, into the open.

Concerns about the exploitation of limited resources, optimum development trajectories, and climate change draw attention to the temporal horizons of our environment - Environmental Futures is a curated collection of essays that explores different ways of knowing the future and how these futures shape contemporary social worlds. * Includes a range of detailed case studies, from ice melting in Antarctica to coal mining in Bangladesh, flooding in Colombia to climate modelling in Egypt * Approaches prognosis as a cultural, political, and material process * Reveals the ways in which authority and expertise may be reinforced, circumscribed, or contested in the process of making a prediction and its aftermath * Offers novel insights on how and why futures come to be significant in the present

Evil never truly dies...and some legends live forever. The dark heart of Bram Stoker's classic is reborn; capturing the voice, tone, style and characters of the original yet with a modern sensibility this novel is perfect for fans of Dracula and contemporary horror. It has been some years since Jonathan and Mina Harker survived their ordeal in Transylvania and, vanquishing Count Dracula, returned to England to try and live ordinary lives. But shadows linger long in this world of blood feud and superstition - and, the older their son Quincey gets, the deeper the shadows that lengthen at the heart of the Harkers' marriage. Jonathan has turned back to drink; Mina finds herself isolated inside the confines of her own family; Quincey himself struggles to live up to a family of such high renown. And when a gathering of old friends leads to unexpected tragedy, the very particular wounds in the heart of the Harkers' marriage are about to be exposed... There is darkness both within the marriage and without - for new evil is arising on the Continent. A naturalist is bringing a new species of bat back to London; two English gentlemen, on their separate tours of the continent, find a strange quixotic love for each other, and stumble into a calamity far worse than either has imagined; and the vestiges of something forgotten long ago is finally beginning to stir...

This accessible text presents a detailed introduction to the use of a wide range of software tools and modeling environments for use in the biosciences, as well as the fundamental mathematical background. The practical constraints presented by each modeling technique are described in detail, enabling the researcher to determine which software package would be most useful for a particular problem. Features: introduces a basic array of techniques to formulate models of biological systems, and to solve them; discusses agent-based models, stochastic modeling techniques, differential equations, spatial simulations, and Gillespie's stochastic simulation algorithm; provides exercises; describes such useful tools as the Maxima algebra system, the PRISM model checker, and the modeling environments Repast Simphony and Smoldyn; contains appendices on rules of differentiation and integration, Maxima and PRISM notation, and some additional mathematical concepts; offers supplementary material at an associated website.

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

The book includes recommendations for COPD from published guidelines (eg, the GOLD, ATS, and NICE guidelines) and presents them in the context of relevant clinical treatment issues. This is an in-depth guide on the management of COPD, concentrating on the impact of COPD on a patient as well as how healthcare professionals can intervene and educate the patient at an early stage and thereby slow the onset of severe symptoms.

When it comes to frameworks, the familiar story of the elephant and the six blind philosophers seems to apply. As each philoso pher encountered a separate part of the elephant, each pronounced his considered, but flawed judgement. One blind philosopher felt a leg and thought it a tree. Another felt the tail and thought he held a rope. Another felt the elephant's flank and thought he stood before a wall. We're supposed to learn about snap judgements from this alle gory, but its author might well have been describing design automation frameworks. For in the reality of today's product development requirements, a framework must be many things to many people. xiv CAD Frameworks: Integration Technology for CAD As the authors of this book note, framework design is an optimi zation problem. Somehow, it has to be both a superior rope for one and a tremendous tree for another. Somehow it needs to provide a standard environment for exploiting the full potential of computer-aided engineering tools. And, somehow, it has to make real such abstractions as interoperability and interchangeability. For years, we've talked about a framework as something that provides application-oriented services, just as an operating system provides system-level support. And for years, that simple statement has hid the tremendous complexity of actually providing those services.

Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.

This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma cological intervention. It is hoped this book will be invaluable for research scientists and clinic ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III. Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . ."

Presented here are authoritative and up-to-date assessments of the homogenous and heterogenous chemical and physical processes occuring in the troposphere and stratosphere, especially during the "ozone hole" event. The book begins with an overview of atmospheric chemistry, followed by reviews of relevant homogenous reactions in the gas phase and the microphysics and physical chemistry of heterogenous processes that occur on, or in aerosols, rain and ice. Low temperature laboratory studies are compared with related fieldwork measurements, particularly in relation to the formation and composition of polar stratospheric clouds. Also discussed are measurements in glacial ice. Finally chemical modelling of the troposphere and stratosphere, including heterogenous processes, is reviewed.

The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.

Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the ‘must-have’ information that clinical professionals treating patients with respiratory conditions need to know. This book provides focused information for all health professionals prescribing drugs for or to patients with a respiratory condition and is an essential guide for pulmonologists, intensive care physicians, emergency medicine doctors and general practitioners and nurse prescribers, in training and in practice.

Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.

The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.

When it comes to frameworks, the familiar story of the elephant and the six blind philosophers seems to apply. As each philoso pher encountered a separate part of the elephant, each pronounced his considered, but flawed judgement. One blind philosopher felt a leg and thought it a tree. Another felt the tail and thought he held a rope. Another felt the elephant's flank and thought he stood before a wall. We're supposed to learn about snap judgements from this alle gory, but its author might well have been describing design automation frameworks. For in the reality of today's product development requirements, a framework must be many things to many people. xiv CAD Frameworks: Integration Technology for CAD As the authors of this book note, framework design is an optimi zation problem. Somehow, it has to be both a superior rope for one and a tremendous tree for another. Somehow it needs to provide a standard environment for exploiting the full potential of computer-aided engineering tools. And, somehow, it has to make real such abstractions as interoperability and interchangeability. For years, we've talked about a framework as something that provides application-oriented services, just as an operating system provides system-level support. And for years, that simple statement has hid the tremendous complexity of actually providing those services."