Political scientists have long wondered whether civic participation can have spillover effects - that is, whether civic participation in one particular domain of public life can lead to more participation in other areas. This book argues that participation can indeed be generative. New participants in participatory governance initiatives can acquire new skills, apply them to new areas of their lives, and join new organizations, even in very poor regions. The evidence is based on a large survey - among the broadest in its class - of participants in community-managed schools (CMS) in rural Honduras and Alta Verapaz, Guatemala, together with case studies and historical institutional analysis. This study is thus more optimistic about the promise of participation than other studies. While it recognizes that participatory arenas are often constrained by features of program design, local context, and national political problems, this book shows that participation is not a dead-end affair. Participation can breed new and unexpected forms of civicness, even in the most unlikely settings.

To what extent does participation in one particular domain of public life lead to wider participation in other areas? Through the use of an unprecedented survey supported by case studies this book explores how participatory governance in community-managed schools can alter the civic and political behaviour of participants.

This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians' toolbox for precision medicine-based patient care. From sample processing to multi-omics approaches, the book provides straight-forward protocols on a wide array of vital areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Proteomics: Methods and Protocols serves as an ideal guide for researchers working to expand upon the knowledge base needed to push forward toward a more personalized version of medicine.

This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians' toolbox for precision medicine-based patient care. From sample processing to multi-omics approaches, the book provides straight-forward protocols on a wide array of vital areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Proteomics: Methods and Protocols serves as an ideal guide for researchers working to expand upon the knowledge base needed to push forward toward a more personalized version of medicine.