This book traces the endeavor in U.S. to develop a means of protecting the people from the effects of nuclear war. It shows how the policies that have emerged are as much products of the political process as of weapons technology.

To many, civil defense stands as a symbol of the futility of society's attempt to escape the consequences of its own creations. Unlike other areas of national security policy, civil defense has never attracted widespread support and has encountered constant difficulties in securing political and financial backing. In addition, rapidly evolving military technology has consistently eroded the substance of the program and its credibility in the eyes of the public. This book traces the continuing endeavor in the United States to develop a means of protecting the American people from the effects of nuclear war. It is a story of frustration and, to a large degree, failure. The book begins with the pre-nuclear period of the two world wars, when political and organizational precedents were established that served as the basis for the Civil Defense Act of 1950. It then recounts the evolution of civil defense practices from the early 1950s to the present, during which time attention was focused, in tum, upon blast shelters, evacuation, fallout shelters, and, currently, crisis relocation. Dr. Kerr shows how the policies that have emerged are as much products of the political process as of weapons technology-how they reflect specific interactions between Congress and the executive branch in an environment marked by apathy on the part of the general public and hostility on the part of articulate groups.

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.
KEY FEATURES:
* One work that can be consulted for all aspects of anticancer drug development
* Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
* A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
* Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
* Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
* Hundreds of references that allow the reader to access relevant scientific and medical literature
* Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Today's economy is rapidly shifting and extremely complex. As we enter this new commercial age, a global restructuring of the business world is underway. Executives must respond to this change by re-imagining their organizations' structures, enhancing product and service offerings, and leveraging emerging technological capabilities in order to keep their organizations vital for years to come.
Written for executives and those aspiring to become one, this book serves as a primer for how to set direction and manage change within the 21stcentury enterprise. Organized into easily accessible checklists, each chapter demystifies a key aspect of today's leadership challenge and outlines the steps necessary to revitalize today's businesses. The 'See It In Action' sidebars provide real world examples of how these concepts are already being implemented in businesses today, featuring companies such as CIGNA HealthCare, Forbes Insights, Virgin Records, DreamWorks Animation, Google, Molex, and Marriott International. Together, these chapter checklists encompass a guide that can be used to institute an overarching, enterprise-wide transformation program and make today's ultra-complex business world a little easier to manage.

Analyzing Intelligence, now in a revised and extensively updated second edition, assesses the state of the profession of intelligence analysis from the practitioners point of view. The contributors-most of whom have held senior positions in the US intelligence community-review the evolution of the field, the rise of new challenges, pitfalls in analysis, and the lessons from new training and techniques designed to deal with 21st century national security problems. This second edition updates this indispensable book with new chapters that highlight advances in applying more analytic rigor to analysis, along with expertise-building, training, and professional development. New chapters by practitioners broaden the original volume's discussion of the analyst-policymaker relationship by addressing analytic support to the military customer as well as by demonstrating how structured analysis can benefit military commanders on the battlefield. Analyzing Intelligence is written for national security practitioners such as producers and users of intelligence, as well as for scholars and students seeking to understand the nature and role of intelligence analysis, its strengths and weaknesses, and steps that can improve it and lead it to a more recognizable profession. The most comprehensive and up-to-date volume on professional intelligence analysis as practiced in the US Government, Analyzing Intelligence is essential reading for practitioners and users of intelligence analysis, as well as for students and scholars in security studies and related fields.

The United States has not elected a woman President in 238 years. Mr. Kerr has written a fictional novel about the first woman President. He delves into the atmosphere in Washington and many of the domestic issues. And, there is a scandal and a terrorist threat. Welcome to Washington, Madam President.

Substance abuse is one of society's most serious problems. Drugs seem to be readily available in virtually every country in the world. Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the welfare of others. The disorder is characterised by a pattern of continued pathological use of a medication, non-medically indicated drug or toxin, that results in repeated adverse social consequences related to drug use, such as failure to meet work, family, or school obligations, interpersonal conflicts, or legal problems. There are on-going debates as to the exact distinctions between substance abuse and substance dependence, but current practice standard distinguishes between the two by defining substance dependence in terms of physiological and behavioural symptoms of substance use, and substance abuse in terms of the social consequences of substance use. This book presents the latest research in the field.

The former Jewel in the Crown of the British Empire, India remains, by any measure, a major economic and political actor on the world scene. Without her extensive railway network—completed against all odds by her British colonial masters—it is impossible to imagine what might have become of the diverse lands and peoples of the subcontinent. These railway networks brought them together as a colony; these networks fostered the nationalism that would be Britain's downfall. This rail network both remade the physical landscape and brought social-cultural cohesion to a diverse and wide-ranging populace. It would be common rail travel that Gandhi would employ to reach the masses. From its romantic mystique to its dangerous reality, it is rail travel today that keeps vital social, cultural, economic and political forces moving. India's railroad history serves as a unique lens to her larger story of triumph over adversity. By 1905, India had the world's fourth largest railway network—a position it retains in the early 21st century. The railroads were at the organizational and technological center of many of the inter-related economic, political, social, cultural, and ecological transformations that produced modern India through, and out of, its colonial past. In addition to this vast technical achievement, and (in keeping with the series focus), there is an equally important and wide-sweeping human-interest tale to be told with evocative vignettes of the triumph of the human spirit (one billion strong!) in the face of great adversity.