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Transferring hematopoietic stem cells and immune cells has continued to be a promising therapeutic alternative and a fascinating area of cell biology as well as a field of persistent procedural problems. This explains why substantial parts of basic research on cell growth and differentiation, immune tolerance and antitumor effects, gene transfer, minimal residual disease and supportive care have settled around clinical transplantation in hematology and oncology. This second volume updates the current role of allogeneic and autologous transplantation in leukemias, lymphomas and solid cancers, including controversial strategies and novel experimental approaches. Outstanding representatives of leading groups guarantee first-hand information and indicate how we can work and cooperate more effectively to the benefit of our patients.
Hematopoietic stem cell and immune cell transplantation has cont-
ued as a promising therapeutic alternative and a fascinating area
of cell biology as well as a field of persistent procedural
problems. This - plains why substantial parts of basic research on
cell growth and d- ferentiation, immune tolerance and antitumor
effects, gene transfer, minimal residual disease and supportive
care have settled around cli- cal transplantation in hematology and
oncology. This second volume again updates the current role of
allogeneic and autologous transpl- tation in leukemias, lymphomas
and solid cancers, including cont- versial strategies and novel
experimental approaches. In particular, cellular immune therapy,
new conditioning strategies, mismatched donor transplantation,
updated clinical transplantation, antiangiogenesis and strategies
against fungal infections are focused upon. Outstanding
representatives of leading groups guarantee fir- hand information
and indicate how we can work and cooperate more effectively to the
benefit of our patients. The editors are indebted to the
Gesellschaft zur Bekampfung der Krebskrankheiten
Nordrhein-Westfalen for a substantial support of the publication.
They also acknowledge the major contribution of Beate Kosel as
coordinator of the editorial work."
Some three decades after bone marrow transplantation was introduced
in the field of hematology and oncology, transplantation today
continues to rapidly grow and expand into a variety of new
modalities. Peripheral blood has been established as an effective
source of autologous progenitor cells. Furthermore, the
graft-versus-leukemia effect has resulted in novel strategies of
adoptive immunotherapy for cancer. Finally, approaches to gene
transfer and therapy are utilizing transplantation methodologies
and can augment their effects. Current results, new developments
and perspectives are presented in this volume. Conventional and
innovative experimental approaches, the past and the future of bone
marrow transplantation are reviewed and discussed by leading
representatives.
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