|
Showing 1 - 25 of
27 matches in All Departments
This practical collection examines methodologies originating from
the benefits of genome-wide approaches to studying epigenetics,
which has opened the emerging field of epigenomics. Focusing on the
areas of cancer, inflammatory and autoimmune disorders, chapters
discuss three main components of the epigenome and their role in
the regulation of gene expression and present a detailed method
section specific to studying each component, including data
analyses, troubleshooting, and feasibility in different
experimental settings. The main topics are high-throughput and
targeted methods for DNA methylation analysis, nucleosome position
mapping, studying epigenetic effects of gut microbiota, optical
imaging for detection of epigenetic aberrations in living cells,
methods for microRNA, and histone code profiling. Written for the
Methods in Pharmacology and Toxicology series, the book includes
the kind of detail and implementation advice to encourage success
in the lab. Authoritative and easily applicable, Epigenetics and
Gene Expression in Cancer, Inflammatory and Immune Diseases aims to
provide pharmacologists, molecular biologists, bioinformaticians,
and toxicologists with a vital background on epigenetics and
state-of-the-art techniques in epigenomics.
This book offers a detailed examination of the living arrangements
and material circumstances of the poor betweeen 1650 and 1850.
Chapters investigate poor households in urban, rural and
metropolitan contexts, and contribute to wider investigations into
British economic and social conditions in the long Eighteenth
century.
Nuclear Receptors focuses on the structural analysis of nuclear
receptors from the initial work using isolated protein domains to
the more recent exciting developments investigating the
conformational shape of full-length receptor complexes. The book
also reviews the structure of key nuclear receptor co-regulatory
proteins. It brings together, for the first time, a comprehensive
review of nuclear receptor structure and the importance of receptor
conformation underpinning allosteric regulation by different
ligands (hormone, drugs, DNA response elements, protein-protein
interactions) and receptor activity. The nuclear receptor
superfamily, including receptors for steroid hormones and
non-steroid ligands, are pivotal to normal physiology, regulating
processes as diverse as reproduction, metabolism, the immune system
and brain development. The first members of the family were cloned
over 25 years ago, which heralded in the idea of a superfamily of
intracellular receptor proteins that bound small molecule ligands:
classical steroid hormones, vitamins, fatty acids and other
products of metabolism. These signals are then transmitted through
multiprotein receptor-DNA complexes, leading to the regulation of
target genes, often in a cell-selective manner. The cloning of the
receptor cDNAs also ushered in an era of unparalleled analysis of
the mechanisms of action of these ligand-activated transcription
factors.
This volume aims to describe a complementary range of molecular,
cell biological, and in vivo protocols used to investigate the
structure-function of nuclear receptors, together with experimental
approaches that may lead to new drugs to selectively target nuclear
receptor-associated diseases. The Nuclear Receptor Superfamily,
Second Edition will benefit those starting out in the nuclear
receptor research field as well as to more established researchers
who wish to apply different methods to a particular receptor or
research problem. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, The Nuclear Receptor Superfamily,
Second Edition aims to ensure successful results in the further
study of this vital field.
Originally published in 1978 Sea Serpents, Sailors and Sceptics
looks at stories of folklore and mythology which have fascinated
sailors from antiquity to the modern day. From stories of large
unauthenticated sea creatures to the Loch Ness Monster, documented
sightings are vast and the book provides a concise survey and
review of the subject of ocean folklore. It shows how some large
sea creatures, such as the giant squid, have been established and
addresses some of the explanations of sea serpents and other sea
creatures as now known, categorised species and offers a
classification of these species that have formulated the
mythologies of the sea throughout time. The book discusses how
relatively little is known about the sea still and offers a
practical look at the possibility that these mythological
creatures, might in fact be, as yet undiscovered species. This book
provides a unique interdisciplinary volume, crossing between the
area of literature and folklore, and natural historians alike, and
will appeal to academics working in the field of natural history
and folklore alike.
Originally published in 1978 Sea Serpents, Sailors and Sceptics
looks at stories of folklore and mythology which have fascinated
sailors from antiquity to the modern day. From stories of large
unauthenticated sea creatures to the Loch Ness Monster, documented
sightings are vast and the book provides a concise survey and
review of the subject of ocean folklore. It shows how some large
sea creatures, such as the giant squid, have been established and
addresses some of the explanations of sea serpents and other sea
creatures as now known, categorised species and offers a
classification of these species that have formulated the
mythologies of the sea throughout time. The book discusses how
relatively little is known about the sea still and offers a
practical look at the possibility that these mythological
creatures, might in fact be, as yet undiscovered species. This book
provides a unique interdisciplinary volume, crossing between the
area of literature and folklore, and natural historians alike, and
will appeal to academics working in the field of natural history
and folklore alike.
Charter schools offer something that public school systems,
parents, and teachers need: a way to experiment with alternative
ways of teaching, motivating students, organizing schools, using
technology, and employing teachers. While people came down on both
sides of support for or against charter schools, everyone was
surprised by how difficult it was to assess charter school
performance. The first part of this book focuses on how to improve
estimates of charter schools' performance, especially their
benefits to students who attend them; the second part suggests how
policymakers can learn more about charter schools and make better
use of evidence. The editors and authors suggest ways states and
localities can improve the quality of data on which charter school
studies are based and trace some of the ways charter school
research influences policy.
Charter schools offer something that public school systems,
parents, and teachers need: a way to experiment with alternative
ways of teaching, motivating students, organizing schools, using
technology, and employing teachers. While people came down on both
sides of support for or against charter schools, everyone was
surprised by how difficult it was to assess charter school
performance. The first part of this book focuses on how to improve
estimates of charter schools' performance, especially their
benefits to students who attend them; the second part suggests how
policymakers can learn more about charter schools and make better
use of evidence. The editors and authors suggest ways states and
localities can improve the quality of data on which charter school
studies are based and trace some of the ways charter school
research influences policy.
Steroid Hormone Receptors in Endocrine Physiology and Diseases
covers the role of steroid hormones in human physiology and
receptor activity in the pathophysiology of disease. The book
discusses how these receptors can be used as therapeutic targets
for the treatment of conditions from cancer to aging, offering
immediate applications of biochemical principles into clinical
applications such as diagnosis and treatment. This book is a
valuable reference for graduate and postdoctoral scientists but is
also ideal for medical students interested in the functional role
of various steroid hormone receptors in a wide variety of endocrine
related diseases.Steroid hormone receptors (SHRs) are known to play
vital roles in normal physiology through the control of
development, differentiation, metabolic homeostasis and
reproduction. Due to their involvement in various pathological and
disease conditions, SHRs are also important therapeutic targets in
several disorders including inflammation, autoimmune diseases,
hormone-dependent cancers, osteoporosis and cardiovascular
diseases.
This volume aims to describe a complementary range of molecular,
cell biological, and in vivo protocols used to investigate the
structure-function of nuclear receptors, together with experimental
approaches that may lead to new drugs to selectively target nuclear
receptor-associated diseases. The Nuclear Receptor Superfamily,
Second Edition will benefit those starting out in the nuclear
receptor research field as well as to more established researchers
who wish to apply different methods to a particular receptor or
research problem. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, The Nuclear Receptor Superfamily,
Second Edition aims to ensure successful results in the further
study of this vital field.
This practical collection examines methodologies originating from
the benefits of genome-wide approaches to studying epigenetics,
which has opened the emerging field of epigenomics. Focusing on the
areas of cancer, inflammatory and autoimmune disorders, chapters
discuss three main components of the epigenome and their role in
the regulation of gene expression and present a detailed method
section specific to studying each component, including data
analyses, troubleshooting, and feasibility in different
experimental settings. The main topics are high-throughput and
targeted methods for DNA methylation analysis, nucleosome position
mapping, studying epigenetic effects of gut microbiota, optical
imaging for detection of epigenetic aberrations in living cells,
methods for microRNA, and histone code profiling. Written for the
Methods in Pharmacology and Toxicology series, the book includes
the kind of detail and implementation advice to encourage success
in the lab. Authoritative and easily applicable, Epigenetics and
Gene Expression in Cancer, Inflammatory and Immune Diseases aims to
provide pharmacologists, molecular biologists, bioinformaticians,
and toxicologists with a vital background on epigenetics and
state-of-the-art techniques in epigenomics.
Nuclear Receptors focuses on the structural analysis of nuclear
receptors from the initial work using isolated protein domains to
the more recent exciting developments investigating the
conformational shape of full-length receptor complexes. The book
also reviews the structure of key nuclear receptor co-regulatory
proteins. It brings together, for the first time, a comprehensive
review of nuclear receptor structure and the importance of receptor
conformation underpinning allosteric regulation by different
ligands (hormone, drugs, DNA response elements, protein-protein
interactions) and receptor activity. The nuclear receptor
superfamily, including receptors for steroid hormones and
non-steroid ligands, are pivotal to normal physiology, regulating
processes as diverse as reproduction, metabolism, the immune system
and brain development. The first members of the family were cloned
over 25 years ago, which heralded in the idea of a superfamily of
intracellular receptor proteins that bound small molecule ligands:
classical steroid hormones, vitamins, fatty acids and other
products of metabolism. These signals are then transmitted through
multiprotein receptor-DNA complexes, leading to the regulation of
target genes, often in a cell-selective manner. The cloning of the
receptor cDNAs also ushered in an era of unparalleled analysis of
the mechanisms of action of these ligand-activated transcription
factors.
This volume provides a brief resume of the history of testosterone
research, from the early pioneers through to the most recent
advances in the field. We discover how steroid hormones were first
identified and how testosterone was shown to be essential for male
development. Moving forward we explore how and where testosterone
is produced, and how the body controls testosterone production. We
then investigate the impact testosterone has on different body
systems both during their development and function, and how
perturbation of testosterone action is associated with disease. We
complete our story with an exploration of the emerging roles of
testosterone in clinical therapy, and the future potential for
manipulation of the testosterone signaling system for human health
benefit.
Companies spend millions of dollars every year trying to court
consumers. They invest in flashy advertising, celebrity
endorsements, loyalty programs, Web sites . . . you name it. And
they spend millions more trying to build their businesses through
elaborate "relationship management" software.The result? Most
marketers still aren't emotionally connecting with consumers. Sure,
their strategies may draw raves, and their ads may win impressive
awards at Cannes. They may even raise their brand awareness. But
they too often fail to build enduring brand relationships. Put
another way: Many marketers are great at wooing a "first date" with
consumers - yet lousy at creating a lasting marriage between buyer
and brand. Married to the Brand tells the story of what makes
profitable brand relationships work - through the eyes of the
consumer, not the marketer. Packed with stories and compelling
discoveries from a worldwide consumer database, this book explores
why people bond with some brands and not others.
This book offers a detailed examination of the living arrangements
and material circumstances of the poor betweeen 1650 and 1850.
Chapters investigate poor households in urban, rural and
metropolitan contexts, and contribute to wider investigations into
British economic and social conditions in the long Eighteenth
century.
The past decade has seen increased attention to cost-effectiveness
and benefit-cost analysis in education as administrators are being
asked to accomplish more with the same or even fewer resources,
philanthropists are keen to calculate their "return on investment"
in social programs, and the general public is increasingly
scrutinizing how resources are allocated to schools and colleges.
This text (titled Cost-Effectiveness Analysis in its previous
editions) is the only full-length book to provide readers with the
step-by-step methods they need to plan and implement a benefit-cost
analysis in education. The authors examine a range of issues,
including how to identify, measure, and distribute costs; how to
measure effectiveness, utility, and benefits; and how to
incorporate cost evaluations into the decision-making process. The
updates to the Third Edition reflect the considerable
methodological development in the evaluation literature, and the
greater empiricism practiced by education researchers, to help
readers learn to apply more advanced methods to their own analyses.
SAGE congratulates author Henry M. Levin, winner of the 2017 AERA
Distinguished Contributions to Research in Education Award.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ The Essentials Of Argumentation Elias J. MacEwan D. C. Heath
& co., 1904 Debates and debating; Logic
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone!
|
You may like...
The Queen
Andrew Morton
Paperback
R375
R300
Discovery Miles 3 000
Loot
Nadine Gordimer
Paperback
(2)
R383
R318
Discovery Miles 3 180
Hampstead
Diane Keaton, Brendan Gleeson, …
DVD
R63
Discovery Miles 630
Poor Things
Emma Stone, Mark Ruffalo, …
DVD
R343
Discovery Miles 3 430
Loot
Nadine Gordimer
Paperback
(2)
R383
R318
Discovery Miles 3 180
|