This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytical methods, and an overview of the drug substance manufacturing process. Preformulation and the development of traditional solutions and lyophilized formulations frequently used for intravenous delivery and non-traditional formulations are also addressed. Because many developments in the field have emerged since the publication of the First Edition, this Second Edition addresses important new patient-friendly developments in the field, such as formulation for implantable devices, needle-free formulation and delivery approaches, and oral delivery of proteins.

According to a major health survey, nearly half of all Americans have been mentally ill at some point in their lives-more than a quarter in the last year. Can this be true? What exactly does it mean, anyway? What's a disorder, and what's just a struggle with real life? This lucid and incisive book cuts through both professional jargon and polemical hot air, to describe the intense political and intellectual struggles over what counts as a "real" disorder, and what goes into the "DSM," the psychiatric bible. Is schizophrenia a disorder? Absolutely. Is homosexuality? It was-till gay rights activists drove it out of the DSM a generation ago. What about new and controversial diagnoses? Is "social anxiety disorder" a way of saying that it's sick to be shy, or "female sexual arousal disorder" that it's sick to be tired? An advisor to the DSM, but also a fierce critic of exaggerated overuse, McNally defends the careful approach of describing disorders by patterns of symptoms that can be seen, and illustrates how often the system medicalizes everyday emotional life. Neuroscience, genetics, and evolutionary psychology may illuminate the biological bases of mental illness, but at this point, McNally argues, no science can draw a bright line between disorder and distress. In a pragmatic and humane conclusion, he offers questions for patients and professionals alike to help understand, and cope with, the sorrows and psychopathologies of everyday life.

How can we design places that fulfill urgent needs of the community, achieve environmental justice, and inspire long-term stewardship? By bringing community members to the table, we open up the possibility of exchanging ideas meaningfully and transforming places powerfully. Collaboration like this is hands-on democracy in action. It's up close. It's personal. For decades, participatory design practices have helped enliven neighborhoods and promote cultural understanding. Yet, many designers still rely on the same techniques that were developed in the 1950s and 60s. These approaches offer predictability, but hold waning promise for addressing current and future design challenges. Design as Democracy: Techniques for Collective Creativity is written to reinvigorate democratic design, providing inspiration, techniques, and case stories for a wide range of contexts. Edited by six leading practitioners and academics in the field of participatory design, with nearly 50 contributors from around the world, Design as Democracy shows how to design with communities in empowering and effective ways. The flow of the book's nine chapters reflects the general progression of community design process, while also encouraging readers to search for ways that best serve their distinct needs and the culture and geography of diverse places. Each chapter presents a series of techniques around a theme, from approaching the initial stages of a project, to getting to know a community, to provoking political change through strategic thinking. Readers may approach the book as they would a cookbook, with recipes open to improvisation, adaptation, and being created anew. Design as Democracy offers fresh insights for creating meaningful dialogue between designers and communities and for transforming places with justice and democracy in mind.

A Grandfather's perspective on bringing up children to have a strong sense of the difference between right and wrong and thereby enable them to have Integrity and understand the meaning of Accountability. Our country is in the grip of an epidemic of corruption. The leadership in the United Staes of America has neither the intestinal fortitude or interest to stop it. This should come as no surprise when, for instance, our government leaders are crafting an Ethics Bill directed to stopping themselves from participating in Insider Trading. They had excluded themselves from prosecution for participating in this corrupt practice when they passed the original Insider Trading Bill When our children become fully fledged grown up citizens with strong Integrity and a knowledge of the meaning of Accountability, we can look forward to a sea change in society insofar as to what it accepts as the norm for ethics and the way we lead our lives. Our country will then change for the better and become a happier place to live in.

Are horrific experiences indelibly fixed in a victim's memory? Or does the mind protect itself by banishing traumatic memories from consciousness? How victims remember trauma is the most controversial issue in psychology today, spilling out of consulting rooms and laboratories to capture headlines, rupture families, provoke legislative change, and influence criminal trials and civil suits. This book, by a clinician who is also a laboratory researcher, is the first comprehensive, balanced analysis of the clinical and scientific evidence bearing on this issue--and the first to provide definitive answers to the urgent questions at the heart of the controversy.

Synthesizing clinical case reports and the vast research literature on the effects of stress, suggestion, and trauma on memory, Richard McNally arrives at significant conclusions, first and foremost that traumatic experiences are indeed unforgettable. Though people sometimes do not think about disturbing experiences for long periods of time, traumatic events rarely slip from awareness for very long; furthermore, McNally reminds us, failure to think about traumas--such as early sexual abuse--must not be confused with amnesia or an inability to remember them. In fact, the evidence for repressed memories of trauma--or even for repression at all--is surprisingly weak.

A magisterial work of scholarship, panoramic in scope and nonpartisan throughout, this unfailingly lucid work will prove indispensable to anyone seeking to understand how people remember trauma.

Dr. McNally critically examines well over 150 years of Oblate and general Catholic history in Canada's western-most province with special emphasis on the Native people and Euro-Canadian settlers. It is the first survey history of the Catholic Church in British Columbia.