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AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976,
M. Thakur et al (1) were the first to publish a paper concerning
the in vivo thrombus detection with 111- In-labelled platelets.
Previous attempts at scintigraphic thrombus localisation had been
disappointing because of the unspecific binding of a number of the
isotopes used, as well as the poor labelling efficiency or an
insufficient low gamma-emitting property. Because of its physical
characteristics (2.8 days half-life, 94% gamma emission) 111 Indium
turned out to be the best isotope for platelet kinetic studies as
well as for the measurement of platelet incorporation by Thrombi to
be used up until now. The lipophile complexes of Ill-In
(8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively
into the platelets without altering the function or the life span
of the platelets. This advantage has let to an increase in the
clinical applications of 1211-In labelled platelets. Today,
radiolabelled platelets are used for thrombus detection in several
different medical areas such as cardiology, nephrology. angiology
or neurology. Even though many scientists and hospital doctors now
routinely use radiolabelled platelet as a diagnostic tool, there is
as yet not a standardized labelling method. In addition to this,
there are neither standardized image procedures for the different
clinical applications nor an agreement about specificity and
sensitivity of the method. In 1983, a symposium on Radiolabelled
Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and
M.D.
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