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Transferring hematopoietic stem cells and immune cells has continued to be a promising therapeutic alternative and a fascinating area of cell biology as well as a field of persistent procedural problems. This explains why substantial parts of basic research on cell growth and differentiation, immune tolerance and antitumor effects, gene transfer, minimal residual disease and supportive care have settled around clinical transplantation in hematology and oncology. This second volume updates the current role of allogeneic and autologous transplantation in leukemias, lymphomas and solid cancers, including controversial strategies and novel experimental approaches. Outstanding representatives of leading groups guarantee first-hand information and indicate how we can work and cooperate more effectively to the benefit of our patients.
Sexual Deviance in Health and Aging: Uncovering Later Life Intimacy
explores life course health experiences and unmet care needs of
populations perceived as sexually deviant in the United States.
These groups include but are not limited to: gay, lesbian, and
bisexual people; asexual and demisexual people; trans, nonbinary,
and gender nonconforming people; intersex people; nonmonogamous and
polyamorous people; kink and fetishism practitioners; sex and adult
entertainment workers; individuals labeled as sexual offenders and
predators; people living with sexually transmitted infections;
people identifying as neuroatypical and/or autistic; and people
with chronic conditions and disabilities who lead active sexual
lives. Lacey J. Ritter and Alexandra C.H. Nowakowski analyze the
social, cultural, and political origins of perceptions of these
groups as sexually deviant. In the process, they provide history
and context for the health care experiences of people within each
of these broad groups. Simultaneously, Sexual Deviance in Health
and Aging highlights the complexity and individuality of different
people's journeys through sexuality in health and aging.
150 years after the first description of the clinical picture of
"white blood" and the introduction of the term "leukemia" by R.
Virchow it appears, that the leukemias, and the acute leukemias in
particular, serve as an impressive example for the major
improvements that have been achieved in the treatment but also in
the understand ing of the biology of malignant dis orders. The
international symposia "Acute Leukemia" which are held at Munster
since 1986 have developed into an interna tional forum to review
the current progress and the future perspectives of leukemia
research and therapy at a high scientific and clinicallevel. Since
the possibility for active participation in these symposia is
somewhat restricted we are glad to have the opportunity to extend
the information that was presented at the symposium "Acute
Leukemias V - Experimental Approaches and Management of Refractory
Disease" which was held from February 27 to March 2, 1994 to a
broader audience of basic scientists and clinicians. This meeting
was especiaIly designed to discuss experimen tal approaches and the
management of refractory disease which allows to evaluate new
experimental therapies on the basis of preclinical studies."
Hematopoietic stem cell and immune cell transplantation has cont-
ued as a promising therapeutic alternative and a fascinating area
of cell biology as well as a field of persistent procedural
problems. This - plains why substantial parts of basic research on
cell growth and d- ferentiation, immune tolerance and antitumor
effects, gene transfer, minimal residual disease and supportive
care have settled around cli- cal transplantation in hematology and
oncology. This second volume again updates the current role of
allogeneic and autologous transpl- tation in leukemias, lymphomas
and solid cancers, including cont- versial strategies and novel
experimental approaches. In particular, cellular immune therapy,
new conditioning strategies, mismatched donor transplantation,
updated clinical transplantation, antiangiogenesis and strategies
against fungal infections are focused upon. Outstanding
representatives of leading groups guarantee fir- hand information
and indicate how we can work and cooperate more effectively to the
benefit of our patients. The editors are indebted to the
Gesellschaft zur Bekampfung der Krebskrankheiten
Nordrhein-Westfalen for a substantial support of the publication.
They also acknowledge the major contribution of Beate Kosel as
coordinator of the editorial work."
Since 1987 Acute Leukemias (AL) has regularly reported on the state
of the art in the rapidly growing, successful and exciting field of
biology and management of these diseases. In this volume large
multicenter clinical trials again form the solid basis for the
investigation of leukemic cell biology, the detection of biologic
subgroups, their differential response to alternative treatment
strategies and the further development of therapy. In particular,
this volume addresses mechanisms of chromosomal translocations and
transcription factors, risk-adapted treatment strategies,
differentiation therapy, secondary AL, special aspects in older
patients, and adoptive immunotherapy. Besides the antileukemic
approaches, supportive treatment with new antimicrobial substances
and growth factors is updated. As a forum of worldwide activities
in the field of AL this volume contains both exhaustive overviews
on major clinical issues and preliminary data and hypotheses not
previously published.
Some three decades after bone marrow transplantation was introduced
in the field of hematology and oncology, transplantation today
continues to rapidly grow and expand into a variety of new
modalities. Peripheral blood has been established as an effective
source of autologous progenitor cells. Furthermore, the
graft-versus-leukemia effect has resulted in novel strategies of
adoptive immunotherapy for cancer. Finally, approaches to gene
transfer and therapy are utilizing transplantation methodologies
and can augment their effects. Current results, new developments
and perspectives are presented in this volume. Conventional and
innovative experimental approaches, the past and the future of bone
marrow transplantation are reviewed and discussed by leading
representatives.
The rates of acute leukemia cure have gradually improved over the
last decade. Clinical study results reflect the impact of
chemotherapy intensity and duration, the role of prolonged
maintenance, intensified consolidation or very early
intensification. Further progress has also been achieved in bone
marrow trans plantation, and recent prospective studies and
meta-analyses have contributed comparisons of the high antileukemic
efficacy of bone marrow transplantation to that of improved
chemotherapy. This allows a more successful combining of the two
forms of treatment. New prognostic factors have emerged from both
cytogenetic and molecular genetic research. Thus, the Philadelphia
chromosome translocation and the bcr/abl gene rearrangement have
proven to be the dominating risk factor in acute lymphoblastic
leukemia. Since the frequency increases with age, differences in
prognosis between children and adults can be explained. Evaluation
of molecular and immunologic leukemia cell markers has provided a
better understanding of residual leukemia in clinical remission, as
a prognostic factor and in monitoring the effectiveness of the
antileukemic strategy. Recent work on leukemic cell biology has
resulted in novel therapeutic approaches such as terminal
differentiation by all-trans-retinoic acid, modulation of
chemotherapy by hematopoietic growth factors such as GM-CSF and
enhancement of immunologic control by cytokines such as interleukin
2. New antimicrobial drugs and the application of mostly empiric
anti-infectious strategies have helped reducing the therapeutic
risk. Thus, a number of recent achievements have provided us with
new options in the management of patients with acute leukemias."
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Johann Caspar Lavater Als Menschen Und Vaterlandsfreund
Geschildert J. Ritter, Johann Caspar Lavater Christlicher
Schriften, 1872
At a time when the stories coming out of New Orleans sounded the
same, we wanted to tell different stories-fiction inspired by New
Orleans librarians who were struggling to put their libraries and
lives back together. Writers and artists worldwide donated works
for this anthology, which benefits Rebuild New Orleans Public
Library. Contributors include: Silvia Barlaam, Donna Beltz, Tanya
Bentham, Moe Biers, D.J. Black, Jason Burger, Greta Cabrel, Rachel
Caine, Gwyneth Cooper, Peg Duthie, Matissa Evensong, S.R. Ferguson,
C.A. Hiley, Bernadette Joseco, Julia Katz, Sasha Katz, Robert
Kelso, Kim Kiser, Charie La Marr, Leochi, Nyssa Anne Madison,
Cynthia Maves, Diana M. McCabe, Emily Moreton, N. Apythia Morges,
Pasquale J. Morrone, T.G. Nossack, A.J. O'Connell, Gloria Oliver,
Eirik Omlie, Aden Penn, Pennswoods, Emma Pocock, Jennifer Racek,
Tamela J. Ritter, Theresa Rogers, Jessica Sims, Shari Smith, Yael
van der Wouden, E.J. Wilson, Autumn Rose Wood, Elizabeth S.C. Wu,
and Caitlin Young.
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