This volume contains a selection of papers presented at Fatigue Design 95 held in Helsinki, Finland from 5-8 September 1995. The papers have been peer reviewed and present practical aspects for the design of components and structures to avoid fatigue failure.
Topics covered include: fatigue design experiences, ground vehicle components, component reliability, multiaxial fatigue, notch analysis, service loading, welded structures, probabilistics aspects in fatigue, fatigue design optimization.

Molecular-based medicine is taking center stage due to the increasing knowledge of breast cancer molecular biology. Treatment tailoring is no longer a dream for the future, but the main goal of current research.

This book provides an overview of the most recent techniques, agents and approaches for breast cancer that contribute to the individualization of treatment. Current biomedical research focuses on facilitating the transfer of molecular biology knowledge into the clinical management of patients, leading to increased survival as well as improved quality of life. Particular attention is given in this book to organ-specific tailored approaches, specific populations, patients preferences and rehabilitation. Also discussed in depth are the respective roles of pharmacotherapeutics modelling, functional imaging, molecular staging, genomics and proteomics and their impact on the "re-classification" of breast cancer, as well as the clinical applications of basic science. The crucial issue of how to optimally integrate biological markers, new technologies and new diagnostic and therapeutic approaches into clinical trials and clinical practice is addressed.

Combining the contributions from authors who are well known experts in these fields with editorial comments, this book provides an overview of the latest achievements in breast cancer and their use in clinical practice.

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Tailoring treatment for individual breast cancers is no longer a dream and is now the main goal for current research. This book gives an overview of the most recent techniques, agents and approaches for breast cancer and the individualization of treatment. Particular attention is given to organ-specific tailored approaches, specific populations, patients' preferences and rehabilitation. Contributions from experts focus on the biomedical research behind the transfer of molecular biology knowledge into the clinical management of patients. This has led to increased survival as well as improved quality of life. The book gives an overview of the latest achievements in breast cancer and their use in clinical practice.

Kids often have strong emotions. But if a child's emotions interfere with school, alienate them from their peers, or cause constant conflicts at home, parents need resources to help calm the chaos. In this much-needed guide, two dialectical behavior therapists offer an activity-based workbook for kids who struggle with anger, mood-swings, and emotional and behavioral dysregulation. Using the skills outlined in this book, kids will be able to manage their emotions, get along with others, and do better in school. In this much-needed guide, two dialectical behavior therapists offer an activity-based workbook for kids who struggle with anger, mood-swings, and emotional and behavioral dysregulation. Using the skills outlined in this book, kids will be able to manage their emotions, get along with others, and do better in school. Childhood can often be a time of intense emotions. But if your child's emotions interfere with school, homework, or tests; alienate them from their peers; make it difficult to forge lasting friendships; or cause constant conflicts at home-it's time to make a change. You need help to calm the chaos now, rather than later. Building on the success of Don't Let Your Emotions Run Your Life and Don't Let Your Emotions Run Your Life for Teens, this is the first dialectical behavior therapy (DBT) activity skills workbook designed especially for kids. Designed for children ages 7 to 12, this essential guide will help kids manage difficult emotions and get along better with others. If you are frustrated or worried about your emotional child, the hands-on activities in this book-including child-friendly mindfulness practices-can help. By reading this book, kids will develop their own "skills tool box" for dealing with intense emotions as they arise, no matter where or when.