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Reflecting the rapid progress in the field, the book presents the
current understanding of molecular mechanisms of
post-transcriptional gene regulation thereby focusing on RNA
processing mechanisms in eucaryotic cells. With chapters on
mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA
editing and others, the book also discusses the critical role of
RNA processing for the pathogenesis of a wide range of human
diseases. The interdisciplinary importance of the topic makes the
title a useful resource for a wide reader group in science, clinics
as well as pharmaceutical industry.
Designed with practical usability in mind, Comprehensive
Dermatologic Drug Therapy, 4th Edition, helps you safely and
effectively treat the skin disorders you're likely to see in your
practice. Dr. Stephen E. Wolverton and new associate editor Dr.
Jashin J. Wu lead a team of global experts to bring you concise,
complete guidance on today's full spectrum of topical,
intralesional, and systemic drugs. You'll prescribe with confidence
thanks to expert coverage of which drugs to use, when to use them,
and adverse effects to monitor. Includes new drug interaction
tables, drug risk profiles, and FDA guidelines, as well as two new
appendices that summarize chapter questions and summarize
highest-risk drug interactions. Covers the best uses for new
biologic therapeutics. Contains new chapters covering medical
decision-making principles, PDE-4 and JAK inhibitors, interleukin
17 inhibitors, interleukin 23 inhibitors, additional biologic
therapeutics, and hedgehog pathway inhibitors. Contains
quick-access summaries of indications/contraindications, dosage
guidelines, drug interactions, drug monitoring guidelines, adverse
effects, and treatment protocols. Features a highly detailed,
disease-specific index, as well as purchase information for major
drugs. Helps you assess your knowledge and prepare for
certification or recertification with about 800 review questions
and answers throughout the book. Enhanced eBook version included
with purchase. Your enhanced eBook allows you to access all of the
text, figures, and references from the book on a variety of
devices.
Protein microarrays have been used for a wide variety of important
tasks, such as identifying protein-protein interactions,
discovering disease biomarkers, identifying DNA-binding specificity
by protein variants, and for characterization of the humoral immune
response. In Protein Microarray for Disease Analysis: Methods and
Protocols, expert researchers provide concise descriptions of the
methodologies currently used to fabricate microarrays for the
comprehensive analysis of proteins or responses to proteins that
can be used to dissect human disease. These methodologies are the
toolbox for revolutionizing drug development and cell-level
biochemical understanding of human disease processes. Beginning
with a section on protein-detecting analytical microarrays, the
volume continues with sections covering antigen microarrays for
immunoprofiling, protein function microarrays, the validation of
candidate targets, proteomic libraries, as well as signal detection
strategies and data analysis techniques. Written in the highly
successful Methods in Molecular Biology (TM) series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and key tips on troubleshooting
and avoiding known pitfalls. Practical and cutting-edge, Protein
Microarray for Disease Analysis: Methods and Protocols serves as a
solid framework to aid scientists in understanding how protein
microarray technology is presently developing and how it can be
applied to transform our analysis of human disease.
Protein microarrays have been used for a wide variety of important
tasks, such as identifying protein-protein interactions,
discovering disease biomarkers, identifying DNA-binding specificity
by protein variants, and for characterization of the humoral immune
response. In Protein Microarray for Disease Analysis: Methods and
Protocols, expert researchers provide concise descriptions of the
methodologies currently used to fabricate microarrays for the
comprehensive analysis of proteins or responses to proteins that
can be used to dissect human disease. These methodologies are the
toolbox for revolutionizing drug development and cell-level
biochemical understanding of human disease processes. Beginning
with a section on protein-detecting analytical microarrays, the
volume continues with sections covering antigen microarrays for
immunoprofiling, protein function microarrays, the validation of
candidate targets, proteomic libraries, as well as signal detection
strategies and data analysis techniques. Written in the highly
successful Methods in Molecular Biology (TM) series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and key tips on troubleshooting
and avoiding known pitfalls. Practical and cutting-edge, Protein
Microarray for Disease Analysis: Methods and Protocols serves as a
solid framework to aid scientists in understanding how protein
microarray technology is presently developing and how it can be
applied to transform our analysis of human disease.
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Mathematical Epidemiology (Paperback)
L.J.S. Allen; Edited by Fred Brauer, Pauline Van Den Driessche; Contributions by C.T. Bauch; Edited by J. Wu; Contributions by …
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R2,508
Discovery Miles 25 080
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Ships in 10 - 15 working days
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Based on lecture notes of two summer schools with a mixed
audience from mathematical sciences, epidemiology and public
health, this volume offers a comprehensive introduction to basic
ideas and techniques in modeling infectious diseases, for the
comparison of strategies to plan for an anticipated epidemic or
pandemic, and to deal with a disease outbreak in real time. It
covers detailed case studies for diseases including pandemic
influenza, West Nile virus, and childhood diseases. Models for
other diseases including Severe Acute Respiratory Syndrome, fox
rabies, and sexually transmitted infections are included as
applications. Its chapters are coherent and complementary
independent units. In order to accustom students to look at the
current literature and to experience different perspectives, no
attempt has been made to achieve united writing style or unified
notation.
Notes on some mathematical background (calculus, matrix algebra,
differential equations, and probability) have been prepared and may
be downloaded at the web site of the Centre for Disease Modeling
(www.cdm.yorku.ca).
A brand-new title in the field of dermatology, Therapy for Severe
Psoriasis provides the ultimate coverage of the treatment options
available for today's most serious cases, including biologics and
oral therapies. It features discussions of the newest drug
therapies, recent FDA-approved biosimilars, and combination
approaches to care, while an overview chapter was designed to aid
those new to the field in understanding the nuances of
difficult-to-treat subtypes of psoriasis. Comprehensive and
focused, Therapy for Severe Psoriasis will be a welcome addition to
the library of any dermatologist seeking in-depth information on
the challenges of this condition. Each of the 16 chapters includes
either an in-depth focus on a single therapy or an overview of a
unique aspect of psoriasis, including: UVB therapy, methotrexate,
acitretin, cyclosporine, apremilast, etanercept, infliximab,
adalimumab, ustekinumab, secukinumab, and ixekizumab. Takes an
evidence-based approach to hard-to-treat severe psoriasis.
Discusses the newest drug therapies (such as ixekizumab), plus
recent FDA-approved biosimilars, a topic unique to this particular
psoriasis text. Presents combination approaches for instances when
standard treatments are not successful. Includes an overview
chapter to help beginners understand the nuances of the disorder.
Expert Consult eBook version included with purchase. This enhanced
eBook experience allows you to search all of the text, figures,
images, and references from the book on a variety of devices.
The evil Empress Dowager Cixi lives And she is determined to
reconquer the world she once ruled by rigging reality itself. Only
the Ruby, an omnipotent gemstone, can thwart Cixi's dastardly
plans, and young Natasha Thorn has been tasked to obtain it in the
lost city of Karhin. During her perilous journey, Natasha meets a
mysterious old man and she finds herself drawn to him. Despite the
great age gap between them, their attraction for each other defies
all logic - as they explore the excitement of a forbidden love at
the expense of both their lives
Silicon is a promising and attractive anode material to replace
graphite for high capacity lithium ion cells since its theoretical
capacity is 10 times of graphite and it is an abundant element on
Earth. However, there are challenges associated with using silicon
as Li-ion anode due to the significant first cycle irreversible
capacity loss and subsequent rapid capacity fade during cycling.
Understanding solid electrolyte interphase (SEI) formation along
with the lithium ion insertion/de-insertion kinetics in silicon
anodes will provide greater insight into overcoming these issues,
thereby lead to better cycle performance. In this paper, cyclic
voltammetry and electrochemical impedance spectroscopy are used to
build a fundamental understanding of silicon anodes. The results
show that it is difficult to form the SEI film on the surface of a
Si anode during the first cycle; the lithium ion insertion and
de-insertion kinetics for Si are sluggish, and the cell internal
resistance changes with the state of lithiation after
electrochemical cycling. These results are compared with those for
extensively studied graphite anodes. The understanding gained from
this study will help to design better Si anodes, and the
combination of cyclic voltammetry with impedance spectroscopy
provides a useful tool to evaluate the effectiveness of the design
modifications on the Si anode performance.
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