0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R5,000 - R10,000 (2)
  • -
Status
Brand

Showing 1 - 2 of 2 matches in All Departments

The Genetic Basis of Alcohol and Drug Actions (Hardcover, 1991 ed.): J.C. Crabbe Jr., R. A. Harris The Genetic Basis of Alcohol and Drug Actions (Hardcover, 1991 ed.)
J.C. Crabbe Jr., R. A. Harris
R5,661 Discovery Miles 56 610 Ships in 10 - 15 working days

HISTORICAL BACKGROUND The use of genetic animal models in neuroscience and biomedical research is showing dramatic growth. The earliest application of these models to research on drug mechanisms was in the area of alcohol research. Mardones (1951) reported successful selective breeding of rats preferring and not preferring to drink alcohol under various conditions of dietary deficiency, suggesting genetic control of alcohol drinking. McClearn and Rodgers (1959, 1961) described differences among inbred mouse strains in preference for 10Ofo ethanol solutions versus tap water. Active exploration of this phenomenon continued until the early 1970s, eventually spawning the entire range of alcohol genetic research reviewed in Chapters 2 and 3 of this volume. Notably, oral alcohol self-administration has served as the basis for the development of several rat lines bred for preference or aversion, and these lines are very actively being investigated. The pioneering research of Dr. McClearn and others was very wide ranging in its conceptual scope and at least touched on all issues currently under intense investigation. The basic approach was to identify high and low preferrers among inbred strains of mice and to search for preference correlates in other traits. One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization. Reviews of these studies concluded that nutritional factors could not completely explain preference differences (Rod gers, 1966; McClearn, 1968)."

The Genetic Basis of Alcohol and Drug Actions (Paperback, Softcover reprint of the original 1st ed. 1991): J.C. Crabbe Jr., R.... The Genetic Basis of Alcohol and Drug Actions (Paperback, Softcover reprint of the original 1st ed. 1991)
J.C. Crabbe Jr., R. A. Harris
R5,458 Discovery Miles 54 580 Ships in 10 - 15 working days

HISTORICAL BACKGROUND The use of genetic animal models in neuroscience and biomedical research is showing dramatic growth. The earliest application of these models to research on drug mechanisms was in the area of alcohol research. Mardones (1951) reported successful selective breeding of rats preferring and not preferring to drink alcohol under various conditions of dietary deficiency, suggesting genetic control of alcohol drinking. McClearn and Rodgers (1959, 1961) described differences among inbred mouse strains in preference for 10Ofo ethanol solutions versus tap water. Active exploration of this phenomenon continued until the early 1970s, eventually spawning the entire range of alcohol genetic research reviewed in Chapters 2 and 3 of this volume. Notably, oral alcohol self-administration has served as the basis for the development of several rat lines bred for preference or aversion, and these lines are very actively being investigated. The pioneering research of Dr. McClearn and others was very wide ranging in its conceptual scope and at least touched on all issues currently under intense investigation. The basic approach was to identify high and low preferrers among inbred strains of mice and to search for preference correlates in other traits. One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization. Reviews of these studies concluded that nutritional factors could not completely explain preference differences (Rod gers, 1966; McClearn, 1968)."

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
MSI B450M-A PRO Max II AMD Gaming…
R1,999 R1,449 Discovery Miles 14 490
Loot
Nadine Gordimer Paperback  (2)
R383 R318 Discovery Miles 3 180
Lucky Define - Plastic 3 Head…
R390 Discovery Miles 3 900
The Matrix 4: Resurrections
Keanu Reeves, Carrie-Anne Moss, … DVD R113 Discovery Miles 1 130
The Personal History Of David…
Dev Patel, Peter Capaldi, … DVD  (1)
R63 Discovery Miles 630
Vital BabyŽ NURTURE™ Breast-Like Feeding…
R259 Discovery Miles 2 590
Burberry London Eau De Parfum Spray…
R2,332 R1,407 Discovery Miles 14 070
Moon Bag (Black)
R57 Discovery Miles 570
Sudocrem Skin & Baby Care Barrier Cream…
R210 Discovery Miles 2 100
Soccer Waterbottle [Black]
R99 R70 Discovery Miles 700

 

Partners