This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need.

• Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations
• Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature
• Contributors are well-known and respected for their work on the specific name reactions.

Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. * Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options * Includes case studies in each chapter * Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines * Explains the advantages of process synthesis versus the synthetic route for drug discovery

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds

Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls.

"Heterocyclic Chemistry in Drug Discovery" is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discoveryStep-by-step descriptions of synthetic methods and practical techniquesExamination of the physical properties for each heterocycle, including NMR data and quantum calculationsDetailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles

"Heterocyclic Chemistry in Drug Discovery" is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Current Drug Synthesis The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas - including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section - the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs. Each chapter includes coverage of background material on a relevant drug class or disease indication and key aspects of drug discovery, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. Readers will also find: Thorough introductions to drugs for infectious diseases, including relebactam, vaborbactam, and baloxavir marboxil In-depth treatments of cancer-treating drugs, including darolutamide, venetoclax, and osimertinib Comprehensive explorations of central nervous system drugs, including zuranolone and risdiplam Extensive discussions of computational drug discovery and peptide drugs Perfect for medicinal, organic, synthetic, and process chemists, Current Drug Synthesis will also earn a place in the libraries of research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

Sets forth the history, state of the science, and future directions of drug discovery

Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design.

"Drug Discovery" features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validationDrug metabolism and pharmacokineticsCentral nervous system drugsIn vitro and in vivo assaysCardiovascular drugsCancer drugs

Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field.

"Drug Discovery" is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Following "Contemporary Drug Synthesis and The Art of Drug Synthesis" (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

The up-to-DATE guide to name reactions in heterocyclic chemistry

Name Reactions in Heterocyclic Chemistry II presents a comprehensive treatise on name reactions in heterocyclic chemistry, one of the most exciting--and important--fields within organic chemistry today.

The book not only covers fresh ground, but also provides extensive information on new and/or expanded reactions in:

Three- and four-membered heterocycles

Five-membered heterocycles (pyrroles and pyrrolidines, indoles, furans, thiophenes, and oxazoles)

Six-membered heterocycles, including pyridines, quinolines, and isoquinolines

Featuring contributions from the leading authorities in heterocyclic chemistry. Each section includes a description of the given reaction, as well as the relevant historical perspective, mechanism, variations and improvements, synthetic utilities, experimental details, and references to the current primary literature.

The reactions covered in Name Reactions in Heterocyclic Chemistry have been widely adopted in all areas of organic synthesis, from the medicinal/pharmaceutical field, to agriculture, to fine chemicals, and the book brings the most cutting-edge knowledge to practicing synthetic chemists and students, along with the tools needed to synthesize new and useful molecules.

"A valuable addition to the literature by any measure and surely will prove its merit in years to come. The new knowledge that arises with its help will be impressive and of great benefit to humankind."
--From the Foreword by E. J. Corey, Nobel Prize Laureate

An invaluable guide to name reactions and reagents for homologations

Name Reactions for Homologations, Part I of Wiley's Comprehensive Name Reactions series comprises a comprehensive treatise on name reactions for homologations. With contributions from world-recognized authorities in the field, this reference offers an up-to-date, concise compilation of the most commonly used and widely known name reactions and reagents. "Part I" discusses Organometallics, Carbon-chain Homologation, and Radical Chemistry.

Arranged alphabetically by name reactions, the listing provides: Description of the reactionHistorical perspectiveA mechanism for the reactionVariations and improvements on the reactionSynthetic utilities of the reactionExperimental detailsReferences to the current primary literature

Armed with this invaluable resource, both students and professionals will have at their fingertips a comprehensive guide to important mechanisms and phenomena in homologation.

Covers important name reactions relevant to heterocyclic chemistry

The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student.

"Name Reactions in Heterocyclic Chemistry" provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles.

Each name reaction is summarized in seven sections:

• Description
• Historical perspective
• Mechanism
• Variations and improvements
• Synthetic utility
• Experimental
• References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - "Name Reactions in Heterocyclic Chemistry" represents a state-of-the-art resource for students and researchers alike.

"A valuable addition to the literature by any measure and surely will prove its merit in years to come. The new knowledge that arises with its help will be impressive and of great benefit to humankind."
--From the Foreword by E. J. Corey, Nobel Prize Laureate

An invaluable guide to name reactions and reagents for homologations

"Name Reactions for Homologations, Part II" of Wiley's Comprehensive Name Reactions series comprises a comprehensive treatise on name reactions for homologations. With contributions from world-recognized authorities in the field, this reference offers an up-to-date, concise compilation of the most commonly used and widely known name reactions and reagents. "Part II" discusses Rearrangements, Asymmetric C-C Bond Formation, and Miscellaneous Homologation Reactions.

Arranged alphabetically by name reactions, the listing provides: Description of the reactionHistorical perspectiveA mechanism for the reactionVariations and improvements on the reactionSynthetic utilities of the reactionExperimental detailsReferences to the current primary literature

Armed with this invaluable resource, both students and professionals will have at their fingertips a comprehensive guide to important mechanisms and phenomena in homologation.

An integrated and insightful look at successful drug synthesis in today's drug discovery market

The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.

"Contemporary Drug Synthesis" examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs.

Authored by four of the pharmaceutical industry's most respected scientists, this timely volume:

• Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others
• Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis
• Organizes the drugs into fourteen therapeutic areas for clarity and ease of useProcess chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. "Contemporary Drug Synthesis" meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.