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Rapid progress has been made in our understanding of the molecular
mechanisms of cell growth and oncogenesis during the past decade.
This book comprises recent results on the regulation of cell growth
in normal and neoplastic tissues by growth factors including
hormones, and by the activation and inactivation of oncogenes and
tumor suppressor genes, respectively. Special attention has been
given to the presentation of the frequently neglected close
correlation between changes in signal transduction and metabolism
pathways during oncogenesis.
This book consists of a series of reviews on selected topics within
the rapidly and vastly expanding field of membrane biology. Its aim
is to highlight the most significant and important advances that
have been made in recent years in understanding the structure,
dynamics, and functions of cell membranes. The progress that is
being made in research in this field is due to the application of
integrated experimental ap- proaches, utilizing sophisticated and
novel techniques in molecular biology, cell biology, biophysics and
biochemistry. Due to the advances made, many problems have been or
are being solved at the molecular level. With the help of an
Editorial Advisory Board consisting of Jean-Pierre Changeux
(Paris), Paolo Comoglio (Torino), Rainer Jaenicke (Regens- burg),
Sten Orrenius (Stockholm), Lorenzo Pinna (Padova), Konrad Sandhoff
(Bonn), and Gottfried Schatz (Basel), we have selected a number of
topics in areas in which progress has been particularly rapid, and
have invited internationally acknowledged experts in the field to
review these topics. The areas covered in this monograph are: 1)
Signal transduction; 2) Membrane traffic: Proteins and lipids; 3)
Bioenergetics: Energy transfer and membrane transport; 4) Cellular
ion homeostasis; 5) Growth factors and adhesion molecules; 6)
Structural analysis of mem- brane proteins; and 7) Membranes and
disease.
Rapid progress has been made in our understanding of the molecular
mechanisms of cell growth and oncogenesis during the past decade.
This book comprises recent results on the regulation of cell growth
in normal and neoplastic tissues by growth factors including
hormones, and by the activation and inactivation of oncogenes and
tumor suppressor genes, respectively. Special attention has been
given to the presentation of the frequently neglected close
correlation between changes in signal transduction and metabolism
pathways during oncogenesis.
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