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Oncology has developed as a subspecialty of medicine with unique
and often complex clinical problems. This handbook ofhematologic
and oncologic emer gencies provides a compact, concise, yet
comprehensive guide to the manage ment of a variety of difficult
clinical situations. The authors of the various chapters are all
clinicians with experience in the management of these difficult
patients. Their efforts provide insight and a ready source of
practical infor mation which lends itself to use in the clinic and
in the inpatient ward. The authors sincerely hope that this
handbook will be of service to house officers and fellows alike, as
they develop skills in the management of the emergent problems of
patients with hematologic and other neoplasms. Janice P. Dutcher
Peter H. Wiernik Bronx, New York;; Contents 1. Syndrome of
Inappropriate Antidiuretic Hormone Secretion and Hyponatremia . . .
. . . . . . . . . . . . . . . . . . . . . 000 . . . . . . . . . . .
Stuart L. Marcus, M.D., Ph.D., and Joachim Z. Fuks, M.D. 1.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 1 2. Mechanisms . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 3 3. Etiology . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 3 4. Diagnosis
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 5 5. Treatment . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 6 References . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 8 2. Acute Tumor Lysis
Syndrome: Prevention and Management . . 9 Stuart L. Marcus, M.D.,
Ph.D., and Avi I. Einz;ig, M.D. 1. Introduction . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 9 2. Risk Factors for the Development of Azotemia in Acute Tumor
Lysis Syndrome........................................... 10 3.
Metabolic Abnormalities That Occur during Acute Tumor Lysis
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 11 . . . . . . . . . . . . . . 4. Prevention of Acute
Tumor Lysis Syndrome: Management prior to Beginning Chemotherapy .
. . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . .
. . 5. Posttreatment Management: Indications for Dialysis . . . . .
. . . . . 14 . . References . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 15 . . . . . . . . . . . . . ."
Oncology has developed as a subspecialty of medicine with unique
and often complex clinical problems. This handbook ofhematologic
and oncologic emer gencies provides a compact, concise, yet
comprehensive guide to the manage ment of a variety of difficult
clinical situations. The authors of the various chapters are all
clinicians with experience in the management of these difficult
patients. Their efforts provide insight and a ready source of
practical infor mation which lends itself to use in the clinic and
in the inpatient ward. The authors sincerely hope that this
handbook will be of service to house officers and fellows alike, as
they develop skills in the management of the emergent problems of
patients with hematologic and other neoplasms. Janice P. Dutcher
Peter H. Wiernik Bronx, New York;; Contents 1. Syndrome of
Inappropriate Antidiuretic Hormone Secretion and Hyponatremia . . .
. . . . . . . . . . . . . . . . . . . . . 000 . . . . . . . . . . .
Stuart L. Marcus, M.D., Ph.D., and Joachim Z. Fuks, M.D. 1.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 1 2. Mechanisms . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 3 3. Etiology . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 3 4. Diagnosis
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 5 5. Treatment . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 6 References . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 8 2. Acute Tumor Lysis
Syndrome: Prevention and Management . . 9 Stuart L. Marcus, M.D.,
Ph.D., and Avi I. Einz;ig, M.D. 1. Introduction . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 9 2. Risk Factors for the Development of Azotemia in Acute Tumor
Lysis Syndrome........................................... 10 3.
Metabolic Abnormalities That Occur during Acute Tumor Lysis
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 11 . . . . . . . . . . . . . . 4. Prevention of Acute
Tumor Lysis Syndrome: Management prior to Beginning Chemotherapy .
. . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . .
. . 5. Posttreatment Management: Indications for Dialysis . . . . .
. . . . . 14 . . References . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 15 . . . . . . . . . . . . . ."
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