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The purpose of Renal Cancer: Methods and Protocols is to introduce
the surgeon, clinician, investigator, and research scientist to the
basic methods employed in the diagnosis and treatment of renal
cancer. Treatment of localized renal cancer is surgical. Treatment
of metastasis with resection, radiotherapy, chemotherapy, and
immunotherapy has had limited results. Therefore, new avenues of
treatment are necessary. In planning this work, I have attempted to
incorporate coverage by specialists from a variety of disciplines,
each applying their individual expertise in renal cancer therapy.
Though many of the participating authors are urologists, there are
also valuable contributions from medical oncologists, laboratory
inv- tigators, and pathologists. One of the inherent problems in
publishing a book that describes molecular techniques, especially
those techniques that are rapidly evolving, is that some of these
may become obsolete after a few years. However, many of the
procedures detailed here are standard approaches that have already
wi- stood the test of time. Reverse transcriptase PCR, or RT-PCR, a
technique that produces m- tiple copies of selected sequences of
DNA, has a sensitivity of a millionfold amplication of a single
cell, and thus constitutes a very precise technique for measuring
the presence of tumor cells. By combining this technique with
genomic hybridization, cadherin, ss and metalloproteinase
expression we may then reveal other important factors in the
detection, staging, aggressiveness, and treatment of this disease.
Prostate Cancer, Science and Clinical Practice, Second Edition,
continues to be an important translational reference that bridges
the gap between science and clinical medicine. It reviews the
biological processes that can be implicated in the disease, reviews
current treatments, highlights the pitfalls where relevant, and
examines the scientific developments that might result in future
treatments. Key chapters from the previous edition have been
updated, and a plethora of new chapters describe new concepts of
prostate cancer biology and newly developed therapeutics. Each
chapter has been written by internationally recognized specialists
on prostate cancer epidemiology, genetic susceptibility, cancer
metastases, prostate physiology, proteomics, new therapeutics, and
clinical trials.
Dr. Mydlo's issue provides a comprehensive review of the diagnosis,
management, and treatment of penile and urethral cancer. Top
experts in the field have supplied state-of-the-art clinical
reviews devoted to core issues, such as Premalignant and early
carcinomas of the penis and scrotum; Histopathology of malignant
lesions of the penis and urethra; Penile cancer: clinical
presentation, diagnosis and staging; Reconstruction of the penis
after surgery; Micrographic surgery for penile tumors; Management
of regional lymphatic drainage; Radiation therapy of cancer of the
penis; and Cancer of male/female urethra.
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