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The use of molecular biology and biochemistry to study the
regulation of gene expression has become a major feature of
research in the biological sciences. Many excellent books and
reviews exist that examine the experimental methodology employed in
specific areas of molecular biology and regulation of gene
expression. However, we have noticed a lack of books, especially
textbooks, that provide an overview of the rationale and general
experimental approaches used to examine chemically or
disease-mediated alterations in gene expression in mammalian
systems. For example, it has been difficult to find appropriate
texts that examine specific experimental goals, such as proving
that an increased level of mRNA for a given gene is attributable to
an increase in transcription rates. Regulation of Gene Expression:
Molecular Mechanisms is intended to serve as either a textbook for
graduate students or as a basic reference for laboratory personnel.
Indeed, we are using this book to teach a graduate-level class at
The Pennsylvania State University. For more details about this
class, please visit http://moltox. cas. psu. edu and select
"Courses. " The goal for our work is to provide an overview of the
various methods and approaches to characterize possible mechanisms
of gene regulation. Further, we have attempted to provide a
framework for students to develop an understanding of how to
determine the various mechanisms that lead to altered activity of a
specific protein within a cell.
The use of molecular biology and biochemistry to study the
regulation of gene expression has become a major feature of
research in the biological sciences. Many excellent books and
reviews exist that examine the experimental methodology employed in
specific areas of molecular biology and regulation of gene
expression. However, we have noticed a lack of books, especially
textbooks, that provide an overview of the rationale and general
experimental approaches used to examine chemically or
disease-mediated alterations in gene expression in mammalian
systems. For example, it has been difficult to find appropriate
texts that examine specific experimental goals, such as proving
that an increased level of mRNA for a given gene is attributable to
an increase in transcription rates. Regulation of Gene Expression:
Molecular Mechanisms is intended to serve as either a textbook for
graduate students or as a basic reference for laboratory personnel.
Indeed, we are using this book to teach a graduate-level class at
The Pennsylvania State University. For more details about this
class, please visit http: //moltox. cas. psu. edu and select
"Courses. " The goal for our work is to provide an overview of the
various methods and approaches to characterize possible mechanisms
of gene regulation. Further, we have attempted to provide a
framework for students to develop an understanding of how to
determine the various mechanisms that lead to altered activity of a
specific protein within a cell.
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