This book constitutes the thoroughly refereed papers of the First International Conference on Applied Informatics, ICAI 2018, held in Bogota, Colombia, in November 2018. The 27 full papers were carefully reviewed and selected from 81 submissions. The papers are organized in topical sections on data analysis; decision systems; health care information systems; IT architectures; learning management systems; mobile information processing systems; robotic autonomy; software design engineering.