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Pharmacological Investigations on Phyllanthus acidus L. Skeels (Paperback): Jain Nilesh Kumar, Singhai Abhay Kumar Pharmacological Investigations on Phyllanthus acidus L. Skeels (Paperback)
Jain Nilesh Kumar, Singhai Abhay Kumar
R1,317 Discovery Miles 13 170 Ships in 10 - 15 working days

In traditional system of Indian medicine, the whole plant of Phyllanthus acidus L. Skeels (Euphorbiaceae) has been widely employed for the treatment of variety of disease including inflammation and hepatic ailments. With this view, the present study was undertaken to investigate the hepatoprotective and anti-inflammatory potential of Phyllanthus acidus. The biochemical and histological changes were monitored to evaluate the extent of hepatic toxicity and inflammation. The methanolic extracts of Phyllanthus acidus at a dose of 200 and 400 mg/kg, showed a significant protective activity in rats against thioacetamide and paracetamol induced hepatotoxicity. The same extract also showed promising anti-inflammatory activity. Phytochemical and chromatographic studies revealed the presence of flavonoids and phenolics in the extract, which suggest that these constituents might be associated with exhibited biological properties.

Simultaneous estimation of antiulcer and antemetic drug by using HPLC (Paperback): Sahu Vinod, Jain Nilesh, Jain Surendra Simultaneous estimation of antiulcer and antemetic drug by using HPLC (Paperback)
Sahu Vinod, Jain Nilesh, Jain Surendra
R1,555 Discovery Miles 15 550 Ships in 10 - 15 working days

A simple, sensitive and validated HPLC method has been developed to determine esomeprazole and domperidone in tablet dosage form. The chromatographic separation was achieved on a hyperchrome C-18 column column (4.6 x 150mm, 5 particle size) analytical column using a mixture of acetonitrile: Phosphate buffer (pH 5.0) in the ratio of 60:40 (v/v) used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 290 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. Linearity of method was found to be in concentration range 10-50 g/ml for esomeprazole and 5-25 g/ml for domperidone with correlation coefficient greater than 0.9999. The retention time of domperidone and esomeprazole was found to be 2.92 and 3.91 min respectively. The method can be used for simultaneous determination of esomeprazole and domperidone."

QSAR Based Design & Synthesis (Paperback): Priyal Jain, Nilesh Jain, Vaibhav Jain QSAR Based Design & Synthesis (Paperback)
Priyal Jain, Nilesh Jain, Vaibhav Jain
R1,304 Discovery Miles 13 040 Ships in 10 - 15 working days

We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

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