In this issue of Anesthesiology Clinics, guest editors Drs. Matthew M. McEvoy and James Abernathy III bring their considerable expertise to the topic of Perioperative Safety Culture. Safety culture is the product of individual and group values, attitudes, perceptions, competencies, and patterns of behavior that determine an organization's health and safety management. In this issue, top experts discuss topics such as patient safety and clinician wellness; handoffs and In-hospital care transitions; team dynamics in the operating room: how is team performance optimized?; anesthesiology operating room medication delivery; OR design: state-of-the-art design concepts to help mitigate errors and improve safety; and more. Contains 16 practice-oriented topics including perioperative safety culture: principles, practices, and pragmatic approaches; what do we know about the system and what are the best practices to stop errors in healthcare; coaching to improve performance; systems of care delivery and optimization in the preoperative arena, operating room, ICU, and postoperative care wards; and more.  Provides in-depth clinical reviews on perioperative safety culture, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.