Over the past 25-30 years, deaths due to Torsades de Pointes (TdP) have resulted in numerous drugs being withdrawn from the market. However, nearly 200 drugs that may prolong the QT interval and cause TdP remain available. A number of drugs with the potential to cause TdP are among the top 200 most prescribed drugs in the US, whilst new information regarding TdP is emerging rapidly. The purpose of this book is to provide a comprehensive source of information on the topic of torsades de pointes (TdP), which is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG). Torsades de Pointes provides a detailed, up-to-date and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of the life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book contains current knowledge, incorporating recent and cutting-edge advances in understanding of topics including inherited channelopathies and congenital LQTS; drugs that cause QT interval prolongation and TdP; non-drug causes of acquired QT interval prolongation and TdP; epidemiology of inherited and acquired TdP; morbidity and mortality associated with TdP, particularly in association with specific antimicrobials, antidepressants and antipsychotics, and methadone; cellular and molecular mechanisms of TdP, traditional and emerging risk factors for TdP; methods of prevention and risk reduction for TdP; and clinical management of patients with TdP. This book is an essential reference for both clinicians and researchers - providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area.

The pain, the struggle, the fear. Many emotions of my life seep threw poetry. From tragic events, personal or life related issues. Each poem tells a story in which many can picture what's being said. Many can feel what has been written because I write from my soul. Life growing up in the ghetto, being at war with my father, coming from a single parent home, are all mixed into what has been developed and what I now bring to as, Tha Ghostwriter's Era...

The pain, the struggle, the fear. Many emotions of my life seep threw poetry. From tragic events, personal or life related issues. Each poem tells a story in which many can picture what's being said. Many can feel what has been written because I write from my soul. Life growing up in the ghetto, being at war with my father, coming from a single parent home, are all mixed into what has been developed and what I now bring to as, Tha Ghostwriter's Era...

Drug-induced diseases are unintended effects of drugs that result in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention and/or require hospitalization. Drug-Induced Diseases provides a detailed overview of diseases that result from drug therapy, arming healthcare professionals with critical knowledge to protect the health and welfare of their patients. Now in its third edition, this important reference helps healthcare practitioners, residents, and students by expanding the understanding of disease state causes and effects, encouraging critical thinking, and raising awareness that many diseases can be caused or exacerbated by a medication the patient is taking. The third edition has been revised and expanded, and includes: * 58 peer-reviewed chapters authored by 99 contributors * Detailed, comprehensive tables * New chapters including Bleeding Disorders, Teratogenicity, and Oral Manifestations of Systemically Administered Drugs * Comprehensive coverage of scores of drug-induced diseases * Information pertaining to the contribution of genetic polymorphisms to specific drug-induced diseases * "Levels of evidence" classification for identifying the strength of evidence that links a listed drug to a specific drug-induced disease * And much more