Updated to reflect the latest thinking and includes new material on Religion and Worldviews and Inclusion and RE A one-stop-shop handbook for new and non-specialist RE teachers looking for a succinct guide to effective teaching and essential subject knowledge. Written by an experienced teacher, teacher education and examiner who knows exactly what teachers are looking for and what they're most concerned about. Cover key areas of teaching such as lesson planning and assessment plus a guide to each Key Stage. Offers a new common-sense pedagogy based on the best of best pedagogies out there, which has been tried, tested and refined in a range of secondary schools in the UK. An emphasis throughout on how religious education can promote understanding, tolerance and respect.

Molecular genetics has revolutionised our understanding of human disease and nowhere is this more apparent than the group of diseases caused by mitochondrial dysfunction. The concept of mitochondrial diseases dates back only as far as the 1960s, and they were given little credence until mutations in mitochondrial DNA were found in the late 1980s. This international edited book summarises the advances in human mitochondrial genetics made over the past decade and a half. During that time, numerous mutations of mitochondrial DNA have been discovered and more recently mitochondrial diseases have been linked to a number of nuclear gene mutations. Although individually rare, mitochondrial diseases collectively represent a common cause of genetic disease. They have myriad effects and often manifest as common disorders such as diabetes, cardiac dysfunction and neurodegenerative disease. Effective treatments are unlikely to be found for some time for the vast majority of mitochondrial disorders and so pre-natal diagnosis and genetic counselling are of primary importance in the management of mitochondrial disease.

In order to make sense of the diversity of mitochondrial disease the reader is first treated to a review of mitochondrial DNA metabolism and normal mitochondrial function. The core of the book details specific mitochondrial and nuclear mutations and the diseases they cause, whilst at the same time providing further insight into mitochondrial function. Later sections assess the role of cellular and animal models in advancing our understanding of mitochondrial diseases and the prospects for novel therapeutic strategies to combat these enigmatic disorders.

Mitochondrial diseases are an increasingly recognised cause of inherited disease. Most clinicians are now aware of this group of diseases and those involved in genetic counselling will recognise the need for a greater understanding of this group of disorders. This book will also appeal to scientific and medical geneticists, and to registrars who encounter this group of diseases in the clinic.

Updated to reflect the latest thinking and includes new material on Religion and Worldviews and Inclusion and RE A one-stop-shop handbook for new and non-specialist RE teachers looking for a succinct guide to effective teaching and essential subject knowledge. Written by an experienced teacher, teacher education and examiner who knows exactly what teachers are looking for and what they're most concerned about. Cover key areas of teaching such as lesson planning and assessment plus a guide to each Key Stage. Offers a new common-sense pedagogy based on the best of best pedagogies out there, which has been tried, tested and refined in a range of secondary schools in the UK. An emphasis throughout on how religious education can promote understanding, tolerance and respect.

In England at the turn of the nineteenth century, the advent of Romanticism coincided with major changes in ideas about children and childhood, eventually resulting in a great flowering of imaginative children's literature. In contrast to the previous century's stern moral tales, children's books began to appeal to the unsullied powers of perception, cognition, and creativity thought by the Romantics to reside in pre-adolescents, and also to the anxieties of adults who longed to reclaim their own lost childhood selves.
These essays document and examine the transformation of children's literature during the Romantic period, and trace Romanticism's influence on Victorian children's literature. Using a variety of critical approaches, including neo-historicist, feminist, mythic, reader-response, and formalist, the contributors challenge established dichotomies in children's literature regarding morality and imagination. Rather, as they demonstrate, a complex interplay of instruction and delight ran throughout nineteenth-century texts for and about children. In addition, they document some of the ways the child was perceived and interpreted, secularized and spiritualized, by such writers as Samuel Taylor Coleridge, William Wordsworth, Maria Edgeworth, Mrs. Sherwood, Hesba Stretton (Sarah Smith), Juliana Ewing, George MacDonald, Lewis Carroll, Frances Hodgson Burnett, and E. Nesbit.

James Holt offers a new answer to the question "What happened to progressivism in the Republican party?" The battles over the Payne-Aldrich tariff, the powers of Speaker Cannon, military preparedness, the elections of 1912 and 1916, and Wilson's New Freedom are used to exemplify the attempts of insurgent Republican Senators to reconcile progressive ideals with party commitment. But these men, Robert La Follette, Albert Cummins, George Norris, and William Borah among them, found that on the national level their efforts aided only the Democrats and that a third party was precluded by their own partisanship and their dependence on Republican constituencies.