This timely edited collection presents a holistic and biopsychosocial analysis of LGBTQ People of Color well-being, focused on heart, brain, and mental health, and employs a unique incorporation of minority stress, intersectionality, and allostatic load frameworks. Bringing together established and emerging academics, its authors present a critical analysis of the latest research that encompasses the study of both risk and resilience factors in LGBTQ People of Color health. Across the book, they highlight the precise nature of the behavioral health disparities experienced by these communities, but further, they reveal the unique roles of intersectional discrimination and structural stigma as mechanisms for these disparities. With chapters also dedicated to federal policies and public health, this multidisciplinary work marks a seminal contribution that will pave the way for further advances in research, theory, and practice. It offers a valuable resource on an understudied population that will appeal to researchers, practitioners and policy makers in the fields of health psychology, public health, epidemiology, sociology, health sciences and medicine.