Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.

Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance. In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Physical Education, Volume 1 James Naismith, Luther Halsey Gulick Triangle Pub. Co., 1892 Education; Physical Education; Education / Physical Education; Physical education and training

Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.

James Naismith invented the game of basketball as a physical education instructor at the International YMCA Training School in Springfield, Massachusetts. That December of 1891, his task was to create a game to occupy a rowdy class during the winter months. Almost instantly popular, the game spread across the country and was played in fifteen countries by the end of the century. And yet basketball never had an overriding presence in Naismith's life, as he was also a minister, doctor, educator, and coach. So what did Naismith think about the game of basketball? In The James Naismith Reader, Douglas Stark answers that question using articles, speeches, letters, notes, radio interview transcripts, and other correspondence, including discussions on the game's origins, Naismith's childhood game duck on a rock in Canada, the changing rules, basketball as a representation of Muscular Christianity, and the physical education movement. From Naismith's original rules written in 1891 to an excerpt from the posthumous publication of his book Basketball: Its Origin and Development, Naismith's writings range over a fifty-year period, showing his thoughts on the game's invention and as the game evolved during his lifetime. The first volume to compile the existing primary sources of Naismith's views on basketball, The James Naismith Reader reveals what its inventor thought of the game, as well as his interactions with educators and instructors who assisted the game's growth.

James Naismith was teaching physical education at the Young Men's Christian Association Training College in Springfield, Massachusetts, and felt discouraged because calisthenics and gymnastics didn't engage his students. What was needed was an indoor wintertime game that combined recreation and competition. One evening he worked out the fundamentals of a game that would quickly catch on. Two peach half-bushel baskets gave the name to the brand new sport in late 1891. Basketball: Its Origin and Development was written by the inventor himself, who was inspired purely by the joy of play. Naismith, born in northern Ontario in 1861, gave up the ministry to preach clean living through sport. He describes Duck on the Rock, a game from his Canadian childhood, the creative reasoning behind his basket game, the eventual refinement of rules and development of equipment, the spread of amateur and professional teams throughout the world, and the growth of women's basketball (at first banned to male spectators because the players wore bloomers). Naismith lived long enough to see basketball included in the Olympics in 1936. Three years later he died, after nearly forty years as head of the physical education department at the University of Kansas. This book, originally published in 1941, carries a new introduction by William J. Baker, a professor of history at the University of Maine, Orono.