A definitive scholarly edition of the correspondence and papers of Thomas Jefferson Congress adjourns early in March, and Jefferson goes home to Monticello for a month. After his return to Washington, he corresponds with territorial governors concerning appointments to legislative councils. He peruses information about Native American tribes, Spanish and French colonial settlements, and the geography of the Louisiana Territory. He seeks the consent of Spanish authorities to a U.S. exploration along the Red River while asserting privately that Spain “has met our advances with jealousy, secret malice, and ill faith.” A new law extends civil authority over foreign warships in U.S. harbors, and he considers using it also to constrain privateers. Federalist opponents bring up “antient slanders” to question his past private and official actions. His personal finances are increasingly reliant on bank loans. He starts a search for a new farm manager at Monticello. Meriwether Lewis and William Clark write from Fort Mandan in April before setting out up the Missouri River. Jefferson will not receive their reports until mid-July. In the Mediterranean, William Eaton coordinates the capture of the port of Derna and Tobias Lear negotiates terms of peace with Pasha Yusuf Qaramanli to end the conflict with Tripoli. News of those events will not reach the United States until September.

After the congressional session ends, Jefferson leaves Washington and goes home to Monticello, where his ailing daughter Mary dies on 17 April. Among the letters of condolence he receives is one from Abigail Adams that initiates a brief resumption of their correspondence. While in Virginia, Jefferson immerses himself in litigations involving land. Back in the capital, he finds that he must reconcile differing opinions of James Madison and Albert Gallatin to settle a claim for diplomatic expenses. He corresponds with Charles Willson Peale about modifications to the polygraph writing machine. He prepares instructions for an expedition to explore the Arkansas and Red Rivers. William Clark and Meriwether Lewis send him maps and natural history specimens from St. Louis. Alexander von Humboldt visits Washington. News arrives that a daring raid led by Stephen Decatur Jr. has burned the frigate Philadelphia to deprive Tripoli of its use. Jefferson is concerned that mediation by Russia or France to obtain the release of the ship's crew could make the United States appear weak. Commodore Samuel Barron sails with frigates to reinforce the squadron in the Mediterranean. Jefferson appoints John Armstrong to succeed Robert R. Livingston as minister to France and attempts to persuade Lafayette to move to Louisiana. In Paris, Napoleon is proclaimed Emperor of the French. Jefferson has "brought peace to our Country and comfort to our Souls," John Tyler writes from Virginia.

A definitive scholarly edition of the correspondence and papers of Thomas Jefferson This volume opens soon after the start of the second session of the Eighth Congress and ends a few days after the session closes. During the period, Jefferson receives twice as many documents as he writes. He sits for portraits by Charles Fevret de Saint-Memin and Rembrandt Peale. The nation endures an extreme winter. William Dunbar begins to send information from the exploration of the Ouachita River. Acts of Congress create new territories and give Orleans Territory an assembly and a path to statehood. The Senate ratifies a treaty to acquire an estimated 50 million acres of land from the Sac and Fox tribes. Levi Lincoln resigns, Robert Smith asks to succeed him as attorney general, and Jefferson seeks a new secretary of the navy. Jefferson and vice-presidential candidate George Clinton receive 162 electoral ballots against 14 for their opponents, Charles Cotesworth Pinckney and Rufus King. Napoleon is crowned emperor of the French, and Spain declares war on Great Britain. The Senate acquits Samuel Chase of eight articles of impeachment. Jefferson prepares his inaugural address and is sworn into office for his second term on 4 March. He refuses to consider serving a third term.

Aaron Burr fells Alexander Hamilton in a duel in July, but Jefferson, caring little for either adversary or for disruptive partisan warfare, gives the event only limited notice. He contends with the problem of filling the offices necessary for the establishment of Orleans Territory on October 1. He is constrained by his lack of knowledge about potential officeholders. Meanwhile, a delegation with a memorial from disgruntled Louisianians travels to Washington. In August, the U.S. Mediterranean squadron bombards Tripoli. The United States has uneasy relationships around its periphery. Jefferson compiles information on British "aggressions" in American ports and waters, and drafts a bill to allow federal judges and state governors to call on military assistance when British commanders spurn civil authority. Another bill seeks to prevent merchant ships from arming for trade with Haiti. Contested claims to West Florida, access to the Gulf of Mexico, tensions along the Texas-Louisiana boundary, and unresolved maritime claims exacerbate relations with Spain. Jefferson continues his policy of pushing Native American nations to give up their lands east of the Mississippi River. Yellow fever has devastating effects in New Orleans. Abigail Adams terminates the brief revival of their correspondence, musing that "Affection still lingers in the Bosom, even after esteem has taken its flight." In November, Jefferson delivers his annual message to Congress. He also commences systematic records to manage his guest lists for official dinners.

Confessing that he may be acting "with more boldness than wisdom," Jefferson in November 1803 drafts a bill to create Orleans Territory, which he entrusts to John Breckinridge for introduction in the Senate. The administration sends stock certificates to France in payment for Louisiana. Relieved that affairs in the Mediterranean have improved with the evaporation of a threat of war with Morocco, the president does not know yet that Tripoli has captured the frigate Philadelphia with its officers and crew. He deals with never-ending issues of appointment to office and quarreling in his own party, while hearing that some Federalists are "as Bitter as wormwood." He shares seeds of the Venus flytrap with Elizabeth Leathes Merry, the British minister's wife. She and her husband, however, create a diplomatic storm over seating arrangements at dinner parties. Having reached St. Louis, Meriwether Lewis reports on the progress of the western expedition. Congress passes the Twelfth Amendment, which will provide for the separate election of president and vice president. In detailed notes made after Aaron Burr calls on him in January, Jefferson records his long-standing distrust of the New Yorker. Less than a month later, a congressional caucus nominates Jefferson for a second term, with George Clinton to replace Burr as vice president. Jefferson makes his first trials of the "double penned writing box" called the polygraph.