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Between the years of 1886 and 1939, the world saw the first
automobiles, rapid urbanization, the decay of empires, vast
economic inequality, the first airplanes and the terrifying secrets
of the atom. It was a time of cataclysmic cultural and
technological transformation in both the United States and the
United Kingdom, and spawned the rise of the literary genres of
science fiction, fantasy and horror. This work assembles gems of
late nineteenth and early twentieth century genre literature,
including stories by literary giants such as H.P. Lovecraft, Robert
E. Howard, C. L. Moore, A. Merritt and E. M. Forster, as well as
smaller authors like Clare Winger Harris, Marie Corelli, William
Hope Hodgson and others. An array of incisive nonfiction pieces on
cultural and scientific advances of the time period provides
context for the anthology's stories.
Speculative modernists-that is, British and American writers of
science fiction, fantasy and horror during the late 19th and early
20th centuries-successfully grappled with the same forces that
would drive their better-known literary counterparts to existential
despair. Building on the ideas of the 19th-century Gothic and
utopian movements, these speculative writers anticipated literary
Modernism and blazed alternative literary trails in science,
religion, ecology and sociology. Such authors as H.G. Wells and
H.P. Lovecraft gained widespread recognition-budding from them,
other speculative authors published fascinating tales of
individuals trapped in dystopias, of anti-society attitudes,
post-apocalyptic worlds and the rapidly expanding knowledge of the
limitless universe. This book documents the Gothic and utopian
roots of speculative fiction and explores how these authors played
a crucial role in shaping the culture of the new century with their
darker, more evolved themes.
If you understand how drugs work (pharmacodynamics), how they are
handled by the body (pharmacokinetics), how they interact with each
other, and how drug treatments are assessed, then you will become a
better prescriber. A Textbook of Clinical Pharmacology and
Therapeutics gives you that understanding.
Fully revised throughout and extensively illustrated, the fifth
edition of this well-established textbook has been streamlined to
focus on what medical students and junior doctors really need to
know in order to understand the implications of prescribing one
drug over, or in combination with, another. The text provides
current information on all areas of drug prescribing with updated
discussion and guidance on such topics as adverse drug reactions,
personalized medicine, gene and cell-based therapy, advances in
cancer therapy, and mechanisms of drug action and treatment
guidelines in HIV and mycobacterial infections therapy. A new
chapter on alternative medicines and nutraceuticals has been
introduced and Further Reading lists have been updated to include
key medical websites.
All medical students and junior doctors who read this book will
learn not only how to use drugs safely and effectively, but,
importantly, the rationale behind effective prescribing decisions.
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