In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

A schoolteacher escapes an abusive marriage and finds love on a blind date. Mary Jane's new man, sure that riding a Harley will restore her confidence, ends up following the white lines with her through fifteen years of marriage. Traveling together, they learn to be partners, both on and off the road, until Dwayne is diagnosed with cancer. After losing her husband, Mary Jane once again must learn to live on her own--but she'll never be the same again.

This is a new release of the original 1925 edition.

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Absolutism in Renaissance Milan shows how authority above the law, once the preserve of pope and emperor, was claimed by the ruling Milanese dynasties, the Visconti and the Sforza, and why this privilege was finally abandoned by Francesco II Sforza (d. 1535), the last duke.
As new rulers, the Visconti and the Sforza had had to impose their regime by rewarding supporters at the expense of opponents. That process required absolute power, also known as "plenitude of power," meaning the capacity to overrule even fundamental laws and rights, including titles to property. The basis for such power reflected the changing status of Milanese rulers, first as signori and then as dukes.
Contemporary lawyers, schooled in the sanctity of fundamental laws, were at first prepared to overturn established doctrines in support of the free use of absolute power: even the leading jurist of the day, Baldo degli Ubaldi (d. 1400), accepted the new teaching. However, lawyers came eventually to regret the new approach and to reassert the principle that laws could not be set aside without compelling justification. The Visconti and the Sforza too saw the dangers of absolute power: as legitimate princes they were meant to champion law and justice, not condone arbitrary acts that disregarded basic rights.
Jane Black traces these developments in Milan over the course of two centuries, showing how the Visconti and Sforza regimes seized, exploited and finally relinquished absolute power.