In this issue of Hematology/Oncology Clinics, guest editors Drs. Sophie Lanzkron and Jane Little bring their considerable expertise to the topic of Sickle Cell Syndromes. Top experts in the field cover key topics such as structural racism and impact on sickle cell disease (SCD); pathophysiology and biomarkers of SCD; genetic modifiers of SCD; allogeneic transplant and gene therapy: reproductive health; chronic pain; and more. Contains 16 relevant, practice-oriented topics including innovative therapies, addressing challenging complications, novel science on mechanisms of disease; preventing cognitive decline in people with SCD; quality of life in SCD; and more. Provides in-depth clinical reviews on sickle cell syndromes, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In the wake of the violent labor disputes in Colorado's two-year Coalfield War, a young woman and single mother resolved in 1916 to change the status quo for 'girls,' as well-to-do women in Denver referred to their hired help. Her name was Jane Street, and this compelling biography is the first to chronicle her defiant efforts - and devastating misfortunes - as a leader of the so-called housemaid rebellion. A native of Indiana, Jane Street (1887 - 1966) began her activist endeavors as an organizer for the Industrial Workers of the World (IWW). In riveting detail, author Jane Little Botkin recounts Street's attempts to orchestrate a domestic mutiny against Denver's elitist Capitol Hill women, including wives of the state's national guard officers and Colorado Fuel and Iron operators. It did not take long for the housemaid rebellion to make local and national news. Despite the IWW's initial support of the housemaids' fight for fairness and better pay, Street soon found herself engaged in a gender war, the target of sexism within the very organization she worked so hard to support. The abuses she suffered ranged from sabotage and betrayal to arrests and abandonment. After the United States entered World War I and the first Red Scare arose, Street's battle to balance motherhood and labor organizing began to take its toll. Legal troubles, broken relationships, and poverty threatened her very existence. In previous western labor and women's studies accounts, Jane Street has figured only marginally, credited in passing as the founder of a housemaids' union. To unearth the rich detail of her story, Botkin has combed through case histories, family archives, and - perhaps most significant - Street's own writings, which express her greatest joys, her deepest sorrows, and her unfortunate dealings with systematic injustice. Setting Jane's story within the wider context of early-twentieth-century class struggles and the women's suffrage movement, The Girl Who Dared to Defy paints a fascinating - and ultimately heartbreaking - portrait of one woman's courageous fight for equality.

Franklin Henry Little (1878-1917), an organizer for the Western Federation of Miners and the Industrial Workers of the World (IWW), fought in some of the early twentieth century's most contentious labor and free-speech struggles. Following his lynching in Butte, Montana, his life and legacy became shrouded in tragedy and family secrets. In Frank Little and the IWW, author Jane Little Botkin chronicles her great-granduncle's fascinating life and reveals its connections to the history of American labor and the first Red Scare. Beginning with Little's childhood in Missouri and territorial Oklahoma, Botkin recounts his evolution as a renowned organizer and agitator on behalf of workers in corporate agriculture, oil, logging, and mining. Frank Little traveled the West and Midwest to gather workers beneath the banner of the Wobblies (as IWW members were known), making soapbox speeches on city street corners, organizing strikes, and writing polemics against unfair labor practices. His brother and sister-in-law also joined the fight for labor, but it was Frank who led the charge - and who was regularly threatened, incarcerated, and assaulted for his efforts. In his final battles in Arizona and Montana, Botkin shows, Little and the IWW leadership faced their strongest opponent yet as powerful copper magnates countered union efforts with deep-laid networks of spies and gunmen, an antilabor press, and local vigilantes. For a time, Frank Little's murder became a rallying cry for the IWW. But after the United States entered the Great War and Congress passed the Sedition Act (1918) to ensure support for the war effort, many politicians and corporations used the act to target labor ""radicals,"" squelch dissent, and inspire vigilantism. Like other wage-working families smeared with the traitor label, the Little family endured raids, arrests, and indictments in IWW trials. Having scoured the West for firsthand sources in family, library, and museum collections, Botkin melds the personal narrative of an American family with the story of the labor movements that once shook the nation to its core. In doing so, she throws into sharp relief the lingering consequences of political repression.

Franklin Henry Little (1878-1917), an organizer for the Western Federation of Miners and the Industrial Workers of the World (IWW), fought in some of the early twentieth century's most contentious labor and free-speech struggles. Following his lynching in Butte, Montana, his life and legacy became shrouded in tragedy and family secrets. In Frank Little and the IWW, author Jane Little Botkin chronicles her great-granduncle's fascinating life and reveals its connections to the history of American labor and the first Red Scare. Beginning with Little's childhood in Missouri and territorial Oklahoma, Botkin recounts his evolution as a renowned organizer and agitator on behalf of workers in corporate agriculture, oil, logging, and mining. Frank Little traveled the West and Midwest to gather workers beneath the banner of the Wobblies (as IWW members were known), making soapbox speeches on city street corners, organizing strikes, and writing polemics against unfair labor practices. His brother and sister-in-law also joined the fight for labor, but it was Frank who led the charge - and who was regularly threatened, incarcerated, and assaulted for his efforts. In his final battles in Arizona and Montana, Botkin shows, Little and the IWW leadership faced their strongest opponent yet as powerful copper magnates countered union efforts with deep-laid networks of spies and gunmen, an antilabor press, and local vigilantes. For a time, Frank Little's murder became a rallying cry for the IWW. But after the United States entered the Great War and Congress passed the Sedition Act (1918) to ensure support for the war effort, many politicians and corporations used the act to target labor ""radicals,"" squelch dissent, and inspire vigilantism. Like other wage-working families smeared with the traitor label, the Little family endured raids, arrests, and indictments in IWW trials. Having scoured the West for firsthand sources in family, library, and museum collections, Botkin melds the personal narrative of an American family with the story of the labor movements that once shook the nation to its core. In doing so, she throws into sharp relief the lingering consequences of political repression.

In the wake of the violent labor disputes in Colorado's two-year Coalfield War, a young woman and single mother resolved in 1916 to change the status quo for "girls," as well-to-do women in Denver referred to their hired help. Her name was Jane Street, and this compelling biography is the first to chronicle her defiant efforts-and devastating misfortunes-as a leader of the so-called housemaid rebellion. A native of Indiana, Jane Street (1887-1966) began her activist endeavors as an organizer for the Industrial Workers of the World (IWW). In riveting detail, author Jane Little Botkin recounts Street's attempts to orchestrate a domestic mutiny against Denver's elitist Capitol Hill women, including wives of the state's national guard officers and Colorado Fuel and Iron operators. It did not take long for the housemaid rebellion to make local and national news. Despite the IWW's initial support of the housemaids' fight for fairness and better pay, Street soon found herself engaged in a gender war, the target of sexism within the very organization she worked so hard to support. The abuses she suffered ranged from sabotage and betrayal to arrests and abandonment. After the United States entered World War I and the first Red Scare arose, Street's battle to balance motherhood and labor organizing began to take its toll. Legal troubles, broken relationships, and poverty threatened her very existence. In previous western labor and women's studies accounts, Jane Street has figured only marginally, credited in passing as the founder of a housemaids' union. To unearth the rich detail of her story, Botkin has combed through case histories, family archives, and-perhaps most significant-Street's own writings, which express her greatest joys, her deepest sorrows, and her unfortunate dealings with systematic injustice. Setting Jane's story within the wider context of early-twentieth-century class struggles and the women's suffrage movement, The Girl Who Dared to Defy paints a fascinating-and ultimately heartbreaking-portrait of one woman's courageous fight for equality.