This volume presents a valuable and readily reproducible collection of established and emerging techniques on modern genetic analyses. Chapters focus on statistical or data mining analyses, genetic architecture, the burden of multiple testing, genetic variance, measuring epistasis, multifactor dimensionality reduction, and ReliefF. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolutionary constraints, relaxation of selection mechanisms, diversity preservation strategies, flexing fitness evaluation, evolution in dynamic environments, multi-objective and multi-modal selection, foundations of evolvability, evolvable and adaptive evolutionary operators, foundation of injecting expert knowledge in evolutionary search, analysis of problem difficulty and required GP algorithm complexity, foundations in running GP on the cloud - communication, cooperation, flexible implementation, and ensemble methods. Additional focal points for GP symbolic regression are: (1) The need to guarantee convergence to solutions in the function discovery mode; (2) Issues on model validation; (3) The need for model analysis workflows for insight generation based on generated GP solutions - model exploration, visualization, variable selection, dimensionality analysis; (4) Issues in combining different types of data. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolutionary constraints, relaxation of selection mechanisms, diversity preservation strategies, flexing fitness evaluation, evolution in dynamic environments, multi-objective and multi-modal selection, foundations of evolvability, evolvable and adaptive evolutionary operators, foundation of injecting expert knowledge in evolutionary search, analysis of problem difficulty and required GP algorithm complexity, foundations in running GP on the cloud - communication, cooperation, flexible implementation, and ensemble methods. Additional focal points for GP symbolic regression are: (1) The need to guarantee convergence to solutions in the function discovery mode; (2) Issues on model validation; (3) The need for model analysis workflows for insight generation based on generated GP solutions - model exploration, visualization, variable selection, dimensionality analysis; (4) Issues in combining different types of data. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics include: modularity and scalability; evolvability; human-competitive results; the need for important high-impact GP-solvable problems;; the risks of search stagnation and of cutting off paths to solutions; the need for novelty; empowering GP search with expert knowledge; In addition, GP symbolic regression is thoroughly discussed, addressing such topics as guaranteed reproducibility of SR; validating SR results, measuring and controlling genotypic complexity; controlling phenotypic complexity; identifying, monitoring, and avoiding over-fitting; finding a comprehensive collection of SR benchmarks, comparing SR to machine learning. This text is for all GP explorers. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolutionary constraints, relaxation of selection mechanisms, diversity preservation strategies, flexing fitness evaluation, evolution in dynamic environments, multi-objective and multi-modal selection, foundations of evolvability, evolvable and adaptive evolutionary operators, foundation of injecting expert knowledge in evolutionary search, analysis of problem difficulty and required GP algorithm complexity, foundations in running GP on the cloud - communication, cooperation, flexible implementation, and ensemble methods. Additional focal points for GP symbolic regression are: (1) The need to guarantee convergence to solutions in the function discovery mode; (2) Issues on model validation; (3) The need for model analysis workflows for insight generation based on generated GP solutions - model exploration, visualization, variable selection, dimensionality analysis; (4) Issues in combining different types of data. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolutionary constraints, relaxation of selection mechanisms, diversity preservation strategies, flexing fitness evaluation, evolution in dynamic environments, multi-objective and multi-modal selection, foundations of evolvability, evolvable and adaptive evolutionary operators, foundation of injecting expert knowledge in evolutionary search, analysis of problem difficulty and required GP algorithm complexity, foundations in running GP on the cloud - communication, cooperation, flexible implementation, and ensemble methods. Additional focal points for GP symbolic regression are: (1) The need to guarantee convergence to solutions in the function discovery mode; (2) Issues on model validation; (3) The need for model analysis workflows for insight generation based on generated GP solutions - model exploration, visualization, variable selection, dimensionality analysis; (4) Issues in combining different types of data. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics include: modularity and scalability; evolvability; human-competitive results; the need for important high-impact GP-solvable problems;; the risks of search stagnation and of cutting off paths to solutions; the need for novelty; empowering GP search with expert knowledge; In addition, GP symbolic regression is thoroughly discussed, addressing such topics as guaranteed reproducibility of SR; validating SR results, measuring and controlling genotypic complexity; controlling phenotypic complexity; identifying, monitoring, and avoiding over-fitting; finding a comprehensive collection of SR benchmarks, comparing SR to machine learning. This text is for all GP explorers. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

This book constitutes the refereed proceedings of the 5th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, EvoBIO 2007, held in Valencia, Spain in April 2007, colocated with the Evo* 2007 events.

The 28 revised full papers were carefully reviewed and selected from 60 submissions. Bringing experts in computer science together with experts in bioinformatics and the biological sciences resulted in contributions on fundamental and theoretical issues, along with a wide variety of papers dealing with different applications areas, such as biomarker discovery, cell simulation and modeling, ecological modeling, fluxomics, gene networks, biotechnology, metabolomics, microarray analysis, phylogenetics, protein interactions, proteomics, sequence analysis and alignment, as well as systems biology

This book presents the refereed joint proceedings of seven workshops on evolutionary computing, EvoWorkshops 2006, held in Budapest in April 2006. 65 revised full papers and 13 revised short papers presented were carefully reviewed and selected from a total of 149 submissions. The book is organized in topical sections including evolutionary bioinformatics, evolutionary computation in communications, networks, and connected systems, and more.

The volume and complexity of biological and biomedical research continues to grow exponentially with cutting-edge technologies such as high-throughput sequencing. Unfortunately, bioinformatics analysis is often considered only after data have been generated, which significantly limits the ability to make sense of complex big data. This unique book introduces the idea of No-Boundary Thinking (NBT) in biological and biomedical research, which aims to access, integrate, and synthesize data, information, and knowledge from bioinformatics to define important problems and articulate impactful research questions. This interdisciplinary volume brings together a team of bioinformatics specialists who draw on their own experiences with NBT to illustrate the importance of collaborative science. It will help stimulate discussion and application of NBT, and will appeal to all biomedical researchers looking to maximize their use of bioinformatics for making scientific discoveries.

This volume presents a valuable and readily reproducible collection of established and emerging techniques on modern genetic analyses. Chapters focus on statistical or data mining analyses, genetic architecture, the burden of multiple testing, genetic variance, measuring epistasis, multifactor dimensionality reduction, and ReliefF. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability.

The ?eld of bioinformatics has two main objectives: the creation and main- nance of biological databases, and the discovery of knowledge from life sciences data in order to unravel the mysteries of biological function, leading to new drugs and therapies for human disease. Life sciences data come in the form of biological sequences, structures, pathways, or literature. One major aspect of discovering biological knowledge is to search, predict, or model speci?c infor- tioninagivendatasetinordertogeneratenewinterestingknowledge.Computer science methods such as evolutionary computation, machine learning, and data mining all have a great deal to o?er the ?eld of bioinformatics. The goal of the 6th EuropeanConference on EvolutionaryComputation, Machine Learning, andDataMininginBioinformatics(EvoBIO2008)wastobringtogetherexperts from these ?elds in order to discuss new and novelmethods for tackling complex biological problems. The 6th EvoBIO conference was held in Naples, Italy on March 26-28, 2008 at the "Centro Congressi di Ateneo Federico II." EvoBIO 2008 was held jointly with the 11th European Conference on Genetic Programming (EuroGP 2008), the 8th European Conference on Evolutionary Computation in Combinatorial Optimisation (EvoCOP 2008), and the Evo Workshops. Collectively, the conf- ences and workshops were organized under the name Evo* (www.evostar.org).