This book, for biochemists and molecular biologists, presents the best and most recent computational tools and approaches for recognizing and analysing biological patterns such as those that occur in DNA, RNA, amino-acid sequences, molecular structural motifs, gene and protein families, and so on. These tools have largely been developed by computer scientists working in such areas as machine learning, computer vision, neural networks, graphics, data compression, statistics, and parallel computing, and a sizable proportion of the biological community needs help and guidance in biological informatics approaches to the rapidly growing databases of molecular and genetic information.