A son's journey through his father's dementia. As a cardiologist, Sandeep Jauhar is trained to think logically and dispassionately about medical problems, and primed to offer his patients reassurance and solutions. But when his father is diagnosed with Alzheimer’s there are no magic treatments or miracle drugs – only the promise of unstoppable decline. For years Jauhar watches his father undergo a distressing transformation. Once a prominent research geneticist and author, he now repeats questions over and over, forgets what he has eaten for breakfast, makes baffling financial decisions and turns into a liability behind the wheel. Jauhar investigates the science of dementia and what actually happens in the brain as we age and our memory falters, uncovering the history of Alzheimer’s from first discovery to the most cutting-edge research, and whether modern treatments offer any hope in a global crisis. A blend of science, history and memoir, My Father’s Brain is a brutally honest and moving account of how Jauhar and his siblings grappled every day with some of life’s toughest questions.

‘Jauhar weaves his own personal and family story into his history of the heart…very effectively… This gives a certain dramatic tension to the book, as it tells the fascinating and rather wonderful history of cardiology.’ –Henry Marsh, New Statesman

A Mail on Sunday Book of the Year

The heart lies at the centre of life. For cardiologist Sandeep Jauhar it is an obsession.

In this fascinating history he interweaves gripping scenes from the operating theatre with the moving tale of his family’s history of heart problems – from the death of his grandfather to the ominous signs of how he himself might die.

Jauhar looks at the pioneers who risked patients’ lives and their own careers, and confronts the limits of medical technology, arguing that how we live is more important than any device or drug we may invent. Heart is the all-encompassing story of the engine of life.

Presented here are modern and classical aspects of cytogenetics as well as biotechnology in relation to improvement of the Festuca-Lolium group of grasses. Festuca and its close relative Lolium are very valuable genera of temperate agriculture. These fascinating genera contain some highly productive, nutritious, and well-adapted grasses widely used for agricultural and recreational purposes world wide. The book is organizedinto 15 chapters devoted to taxonomy and systematics; species evolution and divergence by increase in chromosome number as well as by change in DNA content; genetic control of chromosome pairing and its breeding and phylogenetic implications; B chromosomes, induced polyploidy and haploidy inrelation to varietal improvement; wide hybridization, genome relationships, and plant improvement; genomic balance in relation to hybrid fertility and hererosis breeding; biotechnology and its potential applications in plant improvement. It is of special interest to geneticists, taxonomists, evolutionists, biotechnologists, and plant breeders.

Summarizing landmark research, Volume 2 of this essential series furnishes information on the availability of germplasm resources that breeders can exploit for producing high-yielding cereal crop varieties. Written by leading international experts, this volume offers the most comprehensive and up-to-date information on employing genetic resources to increase the yield of those cereal crops that provide the main source of nutrition for two-thirds of the world. In thirteen succinct chapters, Genetic Resources, Chromosome Engineering, and Crop Improvement: Cereals, Volume 2 focuses on wheat, rice, maize, oats, barley, millet, sorghum, and rye, as well as triticale: a wheat and rye hybrid with great potential. An introductory chapter outlines the cytogenetic architecture of cereal crops, describes the principles and strategies of cytogenetics and breeding, and summarizes landmarks in current research. This sets the stage for the ensuing crop-specific chapters. Each chapter generally provides a comprehensive account of the crop, its origin, wild relatives, exploitation of genetic resources in the primary, secondary, and tertiary gene pools through breeding and cytogenetic manipulation, and genetic enrichment using the tools of molecular genetics and biotechnology. Certain to become the standard reference for improving the yields of these critical grains, this book is the definitive source of information for plant breeders, agronomists, cytogeneticists, taxonomists, molecular biologists, biotechnologists, and graduate students and researchers in these fields.

This book is open access under a CC BY 4.0 license. By 2050, human population is expected to reach 9.7 billion. The demand for increased food production needs to be met from ever reducing resources of land, water and other environmental constraints. Rice remains the staple food source for a majority of the global populations, but especially in Asia where ninety percent of rice is grown and consumed. Climate change continues to impose abiotic and biotic stresses that curtail rice quality and yields. Researchers have been challenged to provide innovative solutions to maintain, or even increase, rice production. Amongst them, the 'green super rice' breeding strategy has been successful for leading the development and release of multiple abiotic and biotic stress tolerant rice varieties. Recent advances in plant molecular biology and biotechnologies have led to the identification of stress responsive genes and signaling pathways, which open up new paradigms to augment rice productivity. Accordingly, transcription factors, protein kinases and enzymes for generating protective metabolites and proteins all contribute to an intricate network of events that guard and maintain cellular integrity. In addition, various quantitative trait loci associated with elevated stress tolerance have been cloned, resulting in the detection of novel genes for biotic and abiotic stress resistance. Mechanistic understanding of the genetic basis of traits, such as N and P use, is allowing rice researchers to engineer nutrient-efficient rice varieties, which would result in higher yields with lower inputs. Likewise, the research in micronutrients biosynthesis opens doors to genetic engineering of metabolic pathways to enhance micronutrients production. With third generation sequencing techniques on the horizon, exciting progress can be expected to vastly improve molecular markers for gene-trait associations forecast with increasing accuracy. This book emphasizes on the areas of rice science that attempt to overcome the foremost limitations in rice production. Our intention is to highlight research advances in the fields of physiology, molecular breeding and genetics, with a special focus on increasing productivity, improving biotic and abiotic stress tolerance and nutritional quality of rice.

This book is open access under a CC BY 4.0 license. By 2050, human population is expected to reach 9.7 billion. The demand for increased food production needs to be met from ever reducing resources of land, water and other environmental constraints. Rice remains the staple food source for a majority of the global populations, but especially in Asia where ninety percent of rice is grown and consumed. Climate change continues to impose abiotic and biotic stresses that curtail rice quality and yields. Researchers have been challenged to provide innovative solutions to maintain, or even increase, rice production. Amongst them, the 'green super rice' breeding strategy has been successful for leading the development and release of multiple abiotic and biotic stress tolerant rice varieties. Recent advances in plant molecular biology and biotechnologies have led to the identification of stress responsive genes and signaling pathways, which open up new paradigms to augment rice productivity. Accordingly, transcription factors, protein kinases and enzymes for generating protective metabolites and proteins all contribute to an intricate network of events that guard and maintain cellular integrity. In addition, various quantitative trait loci associated with elevated stress tolerance have been cloned, resulting in the detection of novel genes for biotic and abiotic stress resistance. Mechanistic understanding of the genetic basis of traits, such as N and P use, is allowing rice researchers to engineer nutrient-efficient rice varieties, which would result in higher yields with lower inputs. Likewise, the research in micronutrients biosynthesis opens doors to genetic engineering of metabolic pathways to enhance micronutrients production. With third generation sequencing techniques on the horizon, exciting progress can be expected to vastly improve molecular markers for gene-trait associations forecast with increasing accuracy. This book emphasizes on the areas of rice science that attempt to overcome the foremost limitations in rice production. Our intention is to highlight research advances in the fields of physiology, molecular breeding and genetics, with a special focus on increasing productivity, improving biotic and abiotic stress tolerance and nutritional quality of rice.

"Intern "is Dr. Sandeep Jauhar's story of his days and nights in residency at a busy hospital in New York City, a trial that led him to question his every assumption about medical care today. Residency--and especially its first year, the internship--is legendary for its brutality, and Jauhar's experience was even more harrowing than most. He switched from physics to medicine in order to follow a more humane calling--only to find that his new profession often had little regard for patients' concerns. He struggled to find a place among squadrons of cocky residents and doctors. He challenged the practices of the internship in "The New York Times," attracting the suspicions of the medical bureaucracy. Then, suddenly stricken, he became a patient himself--and came to see that today's high-tech, high-pressure medicine can be a humane science after all. Jauhar's beautifully written memoir explains the inner workings of modern medicine with rare candor and insight.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

Summarizing landmark research, Volume 2 of this essential series furnishes information on the availability of germplasm resources that breeders can exploit for producing high-yielding cereal crop varieties. Written by leading international experts, this volume offers the most comprehensive and up-to-date information on employing genetic resources to increase the yield of those cereal crops that provide the main source of nutrition for two-thirds of the world. In thirteen succinct chapters, Genetic Resources, Chromosome Engineering, and Crop Improvement: Cereals, Volume 2 focuses on wheat, rice, maize, oats, barley, millet, sorghum, and rye, as well as triticale: a wheat and rye hybrid with great potential. An introductory chapter outlines the cytogenetic architecture of cereal crops, describes the principles and strategies of cytogenetics and breeding, and summarizes landmarks in current research. This sets the stage for the ensuing crop-specific chapters. Each chapter generally provides a comprehensive account of the crop, its origin, wild relatives, exploitation of genetic resources in the primary, secondary, and tertiary gene pools through breeding and cytogenetic manipulation, and genetic enrichment using the tools of molecular genetics and biotechnology. Certain to become the standard reference for improving the yields of these critical grains, this book is the definitive source of information for plant breeders, agronomists, cytogeneticists, taxonomists, molecular biologists, biotechnologists, and graduate students and researchers in these fields.

The Mughal emperor Humayun (1508-56) ruled over parts of modern-day India, Afghanistan and Pakistan during his eventful reign. He came to the throne at the age of twenty-two in 1530 and thereafter faced a series of challenges to his control. Throughout this time he was served by his water-bearer, Jauhar, who later wrote these memoirs of his master and his campaigns. This translation from Persian to English was first published in 1832 by Charles Stewart (1764-1837), who had been a professor of oriental languages at the East India College, Haileybury. Jauhar gives a valuable eyewitness narrative of events during a fraught period of Indian history, also providing an insight into Humayun's character. The work begins with an account of his victory over Bahadur Shah and the conquest of Gujarat in the 1530s. It goes on to describe battles with Sher Shah Suri and other campaigns until his death.