This book constitutes the refereed proceedings of the 25th International Conference on Case-Based Reasoning Research and Development, ICCBR 2017, held in Trondheim, Norway, in June 2017. The 27 full papers presented together with 3 keynote presentations were carefully reviewed and selected from 38 submissions. The theme of ICCBR-2017, "Analogy for Reuse", was highlighted in several events. These papers, which are included in the proceedings, address many themes related to the theory and application of case-based reasoning, analogical reasoning, CBR and Deep Learning, CBR in the Health Sciences, Computational Analogy, and Process-Oriented CBR.