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The dramatic advances in molecular genetics are becoming
incorporated into neurobiologic studies at an ever increasing rate.
In developmental neurobiology, the importance of cell cell
interactions for neurogenesis and gene expression is be ginning to
be understood in terms of the molecular bases for these
interactions. This book seeks to emphasize the importance of
molecular technology in the study of neurogenetic mechanisms and to
explore the possible relationships between specific cell cell
interactions and regulated gene expression in the develop ing
nervous ~stem. This volume consists of nineteen chapters which
address ques tions of gene expression and the importance of
cell-cell interac tions as key factors in the developing nervous
~stem. Rather than viewing these two processes as separate
mechanisms, as the organi zation of these chapters might suggest,
we would like to emphasize the interplay of these genetic and
epigenetic influences in all phases of neural ontogeny, a concept
which is made clear by the subject matter of the contributions
themselves. The authors of these chapters were participants in
selected ~mposia from the Fourth Congress of the International
Society of Developmental Neuroscience held in Salt Lake City, Utah,
July 3-7, 1983.
One of the most impressive advances in the field of neuroscience
over the last decade has been the accumulation of data on
plasticity and regeneration in the nervous system of mammals. The
book represents the contribution of a qroup of neuroscientists to
this rapidly expanding field, through a Conference organized by the
Institute of Developmental Neuroscience and Aging (IDNA). The
meeting was held in Torino, Italy during April 1990 in honor of a
great pioneer in the field of Neuroembryology, Professor Guido
Filogamo. His introduction of the concept of neuroplasticity has
had a significant impact on the study of neurobiology. This volume
is divided into six sections, each focusing on one of the subject
areas covered during the meeting Molecular and Cellular Aspects of
Central and Peripheral Nervous System Development; Hormones,*
Growth Factors, Heurotransmi tters, Xenobiotics and Development; In
Vivo and in Vitro models of Development; Development and Regulation
of Glia; Regeneration; and Aging.
The last decade has generated a multitude of studies using in vitro
model systems to explore growth and differentiation of the nervous
system. Although the findings have been exciting and have revealed
unique properties of neural cells, considerable concern continues
to be expressed regarding the significance of in vitro findings in
terms of their applicability to in vivo biological events. To
examine this issue further, a group of scientists pre sented and
discussed their findings at a conference sponsored by the Institute
of Developmental Neuroscience and Aging held in Crete, Greece,
26-29 May 1985. The conference was cosponsored by the University of
Crete and was generously supported by the Ministry of Research and
Technology of Greece, Tourism Organization of Greece, and also
Sandoz and FIDIA. The Directors of the Institute of Developmental
Neuroscience and Aging are indebted to these Institutions for their
support. For the success of this conference, the Directors owe much
to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who
spent countless hours in making arrangements so that the
participants would have not only a scientific, but also a unique
cultural, experience. Several chapters of this book focus on the
complex phenomena of neurogenesis and gliogenesis, and the
modulation of neuronal differentiation. The concept that neuronal
differentiation has both genetic and epigenetic components is
documented by elegant studies using both in vitro cultured cells
and neurons transplanted in vivo."
The last decade has generated a multitude of studies using in vitro
model systems to explore growth and differentiation of the nervous
system. Although the findings have been exciting and have revealed
unique properties of neural cells, considerable concern continues
to be expressed regarding the significance of in vitro findings in
terms of their applicability to in vivo biological events. To
examine this issue further, a group of scientists pre sented and
discussed their findings at a conference sponsored by the Institute
of Developmental Neuroscience and Aging held in Crete, Greece,
26-29 May 1985. The conference was cosponsored by the University of
Crete and was generously supported by the Ministry of Research and
Technology of Greece, Tourism Organization of Greece, and also
Sandoz and FIDIA. The Directors of the Institute of Developmental
Neuroscience and Aging are indebted to these Institutions for their
support. For the success of this conference, the Directors owe much
to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who
spent countless hours in making arrangements so that the
participants would have not only a scientific, but also a unique
cultural, experience. Several chapters of this book focus on the
complex phenomena of neurogenesis and gliogenesis, and the
modulation of neuronal differentiation. The concept that neuronal
differentiation has both genetic and epigenetic components is
documented by elegant studies using both in vitro cultured cells
and neurons transplanted in vivo."
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