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"Mycobacterium tuberculosis" is one of the most notorious
pathogens on earth, causing the death of approximately 1.5 million
people annually. A major problem in the fight against tuberculosis
is the emergence of strains that have acquired resistance to all
available antibiotics. One key to the success of "M. tuberculosis"
as a pathogen is its ability to circumvent host immune responses at
different levels. This is not only a result of the special makeup
of "M. tuberculosis" in terms of genetic diversity and DNA
metabolism and its possession of specialized secretion systems, but
also of its ability to hijack the host s innate immune defence
mechanisms.
In this volume, researchers from different disciplines provide a
topical overview of the diverse mechanisms that contribute to the
virulence of "M. tuberculosis," ranging from their genetic,
metabolic and molecular makeup, as well as the complex strategies
these bacteria utilize to escape immune destruction within infected
hosts."
Mycobacterium tuberculosis is one of the most notorious pathogens
on earth, causing the death of approximately 1.5 million people
annually. A major problem in the fight against tuberculosis is the
emergence of strains that have acquired resistance to all available
antibiotics. One key to the success of M. tuberculosis as a
pathogen is its ability to circumvent host immune responses at
different levels. This is not only a result of the special makeup
of M. tuberculosis in terms of genetic diversity and DNA metabolism
and its possession of specialized secretion systems, but also of
its ability to hijack the host's innate immune defence mechanisms.
In this volume, researchers from different disciplines provide a
topical overview of the diverse mechanisms that contribute to the
virulence of M. tuberculosis, ranging from their genetic, metabolic
and molecular makeup, as well as the complex strategies these
bacteria utilize to escape immune destruction within infected
hosts.
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