This volume explores the latest developments in the study of the mechanisms, diagnostics, screening methods, and therapeutics of colorectal cancer. The book's chapters are divided into three parts: the chapters in Part One examine techniques used to study the molecular mechanisms in colorectal cancer development and progression. Part Two focuses on the innovative tools used to diagnose and detect cancer lesions in the early stages of cancer. Finally, Part Three discusses recent advancements in treating colorectal tumors and identifying new therapeutic molecules for treatment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Colorectal Cancer: Methods and Protocols is a valuable resource for any scientist and researcher interested in this field of study.

From visionary creators Robert Kirkman (The Walking Dead), Cory Walker (Science Dog), and Ryan Ottley (Amazing Spider-Man), it's here: the third massive paperback collection of the greatest comic in the universe. Witness the conclusion of Mark Grayson's epic adventures, from "The Death of Everyone" to "The End of All Things." Collects INVINCIBLE #97-144.

Welcome to Outpost Zero: the smallest town in the universe. The people there work the land, go to the fights every Friday night, and tuck their children into bed... but the Outpost is no place for dreams. To survive is ambitious enough. As Alea and her friends graduate to adulthood under the artificial sky of a faulty biome, on a frozen world never meant to support human life, tragedy strikes. And after the inexplicable suicide of her friend Steven, Alea searches for the reason why - and what she discovers will upend her world forever. Meanwhile, a devastating storm has trapped the Outpost under ice, threatening the entire community's survival. As the Planning Team ventures out into the Frost to save the town, Alea and her friends uncover greater mysteries buried beneath the surface.

In the aftermath of Robot's attempt to take over the world, the few survivors that remain must pick up the pieces of a world once familiar... but now completely alien. From visionary creators Robert Kirkman (The Walking Dead), Cory Walker (Science Dog), and Ryan Ottley (Amazing Spider-Man). Collects Invincible #115-120.

While Mark Grayson and Eve have been gone... things have gotten worse on Earth. And their lives will never be the same again. From visionary creators Robert Kirkman (The Walking Dead), Cory Walker (Science Dog), and Ryan Ottley (Amazing Spider-Man). Collects INVINCIBLE #121-132.

A new beginning for Invincible as things take a turn down a dark path. Everything changes as Invincible is betrayed by one of his own, and Earth will never be the same. From visionary creators Robert Kirkman (The Walking Dead), Cory Walker (Science Dog), and Ryan Ottley (Amazing Spider-Man). Collects INVINCIBLE #109-120.

Welcome back to the smallest town in the universe! Deep in the Outpost, Alea and Sam make a new friend who knows a lot more than they do, and finally get to ask the questions that have been building since Steven's death... hopefully their friendship can survive the answers. Collects OUTPOST ZERO #10-14.

THE END OF ALL THINGSï¿9;the final INVINCIBLE storyï¿9;is collected in one volume. This mega-story touches every corner of the Invincible Universe, and when it's over... MARK GRAYSON'S STORY IS OVER. Every single story for the past 13 years has been leading up to this! From visionary creators Robert Kirkman (The Walking Dead), Cory Walker (Science Dog), and Ryan Ottley (Amazing Spider-Man). Collects INVINCIBLE #133-144.

I HATE FAIRYLAND and DEADPOOL writer SKOTTIE YOUNG and artist AARON CONELY (SABERTOOTH SWORDSMAN, ROCKET RACCOON & GROOT) team up in book one of this debut series! Rufus has been the biggest bully in Rottenville since kindergarten, but on the first day of high school he's gone from bully to bullied. He's forced to make a shaky pact with his favorite geeks, Spencer and his twin sibling besties, Edith and Ernie, as he must survive the Hunger Games-like contest simply known as the BULLY WARS where the winner will rule the school! Collects BULLY WARS #1-5

The knights of Kelodia are the finest in the land, but they've never faced a POWER like the one that resides in the GREEN VALLEY. Now they're about to embark on the adventure of a lifetime-to stop a wizard and slay his dragons-but there's no such thing as magic or dragons... is there? Max Landis (Chronicle, Superman: American Alien) and Giuseppe Camuncoli welcome you to the world of Green Valley...where nothing is ever what it seems. Collects GREEN VALLEY #1-9.