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From within complex structures of organisms and cells down to the
molecular level, biological processes all involve movement.
Muscular fibers slide on each other to activate the muscle, as
polymerases do along nucleic acids for replicating and transcribing
the genetic material. Cells move and organize themselves into
organs by recognizing each other through macromolecular
surface-specific interactions. These recognition processes involve
the mu tual adaptation of structures that rely on their
flexibility. All sorts of conformational changes occur in proteins
involved in through-membrane signal transmission, showing another
aspect of the flexibility of these macromolecules. The movement and
flexibility are inscribed in the polymeric nature of essential
biological macromolecules such as proteins and nucleic acids. For
instance, the well-defined structures formed by the long protein
chain are held together by weak noncovalent interac tions that
design a complex potential well in which the protein floats,
permanently fluctuating between several micro- or
macroconformations in a wide range of frequencies and ampli tudes.
The inherent mobility of biomolecular edifices may be crucial to
the adaptation of their structures to particular functions.
Progress in methods for investigating macromolecular structures and
dynamics make this hypothesis not only attractive but more and more
testable.
Protein Structures: The Cooperative Substructure of Protein
Molecules; Y. Bai, S.W. Englander. Protein Folding: Approaches to
the Determination of More Accurate Crossrelaxation Rates and the
Effects of Improved Distance Constraints on Protein Solution
Structures; G.C. Hoogstraten, J.L. Markley. Protein Interactions:
How Conventional Antigens and Superantigens Interact with the Human
MHC Class II Molecule HLADR1; T. Jardetzky. Nucleic Acids and
Nucleic Acid-Protein Interactions: Stimulating the Dynamics of the
DNA Double Helix in Solution; M. Hirshberg, M. Levitt. Membranes:
Applications of Multidimensional Solidstate NMR Spectroscopy to
Membrane Proteins; A. Ramamoorthy, et al. Carbohydrate Structure:
Conformation, Mobility, and Function of the N-linked Glycan in the
Adhesion Domain of Human CD2; G. Wagner, et al. Abstracts from
Course: Protein Structures Abstracts: Solution Structure of the
ETS-domain from Murine Ets1: A Winged-helix-turn-helix Motif; L.W.
Donaldson. Protein Interactions Abstracts: Designing Mutant
Hemoglobins; M. Madrid, et al. Nucleic Acids and Nucleic
Acid-Protein Interactions Abstracts: A Study on the Dynamics of a
DNA Binding Protein; L.M. Horstink, et al. Poster Abstracts. 55
additional articles. Index.
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