This book constitutes the refereed post-proceedings of the Second International Workshop on Construction and Analysis of Safe, Secure, and Interoperable Smart Devices, CASSIS 2005. The 9 revised full papers presented were carefully selected during two rounds of reviewing and improvement from about 30 workshop talks. The papers are organized in topical sections on research trends in smart devices, Web services, virtual machine technology, security, validation and formal methods, proof-carrying code, and embedded devices.