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Undoubtedly the chemistry of phosphorus appears more and more
attractive in the sense that phosphorus presents an extraordinary
versatile behaviour that allows the synthesis of a large number of
different phosphorus reagents usable for applications in different
fields, from biology to material science without f- getting key
applications in catalysis. The full maturity of this topic of
research can be explained by all the acquired knowledge over these
twenty last years. Organic and inorganic chemistries of P , P and P
species have been the s- in ]V v ject of thousands of publications
while the chemistry of low coordinated ph- phorus derivatives
experienced its hour of glory from the 1970s to the early 1990s. In
parallel, interactions between phosphorus compounds and transition
metals afforded many complexes, a lot of which present fascinating
properties as catalysts. The interest in all these themes really is
not decreasing, indeed some fas- nating areas of research are
emerging or are the subject of many investigations: the medicinal
chemistry of bisphosphonates, the role of phosphorus in biology,
phosphorus ligands in radiopharmaceutical chemistry, phosphorus in
material science, new polymers and dendrimers incorporating
phosphorus, and as- metric catalysis to name but a few. Indeed
researchers, benefitting from their background in basic phosphorus
chemistry are developing many new fields of research.
Dendrimers, which are hyperbranched synthetic macromolecules, have
attracted researchers' increasing interest over the last three
decades owing to their numerous properties, in particular, in the
fields of biology and nanomedicine. This book is an up-to-date
collection of the most recent achievements in the use of dendrimers
in nanomedicine, exemplified by phosphorus-containing dendrimers.
Starting with the synthesis and characterization of phosphorus
dendrimers, the book discusses their use as biomaterials, carriers
of biological entities, and anti-inflammatory drugs; in bioimaging;
and against prion diseases, Alzheimer's, HIV, and cancer. It
compares phosphorus dendrimers with other types of dendrimers.
Supplemented with numerous references and abundant illustrations,
the book opens new perspectives for the researchers working on
dendrimers.
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