Dedicated to the life and work of Francisco Varela, this is an issue of the journal Cybernetics and Human Knowing.

Cybernetics and human knowing: a journal of second-order cybernetics, autopoieses and cyber-semiotics.A quarterly international multi- and transdisciplinary journal devoted to the new understandings of the self-organizing processes of information in human knowing that have arisen through the cybernetics of cybernetics, or second order cybernetics, its relation and relevance to other interdisciplinary approaches such as C.S. Pierce's semiotics.