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The mechanisms and physiological functions of urea transporters
across biological membranes are subjects of long-standing
interests. Although urea represents roughly 40% of all urinary
solutes in normal human urine, the handling of urea in the tissues
has been largely neglected in the past and few clinical or
experimental studies now report data on urea. Most recent
physiological text books include chapters on water and electrolyte
physiology but no chapter on urea. Our aim in writing this book is
to stimulate further research in new directions by providing novel
and provocative insights into the further mechanisms and
physiological significance of urea metabolism and transport in
mammals. This book offers a state-of-the-art report on recent
discoveries concerning urea transport and where the field is going.
It mainly focuses on advances made over the past 20 years on the
biophysics, genetics, protein structure, molecular biology,
physiology, pathophysiology and pharmacology of urea transport in
mammalian cell membranes. It will help graduate students and
researchers to get an overall picture of mammalian urea
transporters and may also yield benefits for pharmaceutical
companies with regard to drug discovery based on the urea
transporter. Baoxue Yang is a professor and vice chairman of the
Department of Pharmacology, Peking University. He is also an
adjunct professor of Jilin University and a visiting professor of
Northeast Normal University. Prof. Yang has been researching urea
transporters for nearly 20 years and has published more than 70
original research articles in this field.
The mechanisms and physiological functions of urea transporters
across biological membranes are subjects of long-standing
interests. Although urea represents roughly 40% of all urinary
solutes in normal human urine, the handling of urea in the tissues
has been largely neglected in the past and few clinical or
experimental studies now report data on urea. Most recent
physiological text books include chapters on water and electrolyte
physiology but no chapter on urea. Our aim in writing this book is
to stimulate further research in new directions by providing novel
and provocative insights into the further mechanisms and
physiological significance of urea metabolism and transport in
mammals. This book offers a state-of-the-art report on recent
discoveries concerning urea transport and where the field is going.
It mainly focuses on advances made over the past 20 years on the
biophysics, genetics, protein structure, molecular biology,
physiology, pathophysiology and pharmacology of urea transport in
mammalian cell membranes. It will help graduate students and
researchers to get an overall picture of mammalian urea
transporters and may also yield benefits for pharmaceutical
companies with regard to drug discovery based on the urea
transporter. Baoxue Yang is a professor and vice chairman of the
Department of Pharmacology, Peking University. He is also an
adjunct professor of Jilin University and a visiting professor of
Northeast Normal University. Prof. Yang has been researching urea
transporters for nearly 20 years and has published more than 70
original research articles in this field.
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