This book constitutes the refereed proceedings of the 6th China Conference on Knowledge Graph and Semantic Computing, CCKS 2021, held in Guangzhou, China, in November 2021. The 19 revised full papers and 9 short papers presented were carefully reviewed and selected from 170 submissions. The papers are organized in topical sections on knowledge extraction: knowledge graph representation and reasoning; knowledge acquisition and knowledge graph construction; linked data, knowledge integration, and knowledge graph storage management; natural language understanding and semantic computing; knowledge graph applications: semantic search, question answering, dialogue, decision support, and recommendation; knowledge graph open resources.