With the rapid growth of networking and high-computing power, the demand for large-scale and complex software systems has increased dramatically. Many of the software systems support or supplant human control of safety-critical systems such as flight control systems, space shuttle control systems, aircraft avionics control systems, robotics, patient monitoring systems, nuclear power plant control systems, and so on. Failure of safety-critical systems could result in great disasters and loss of human life. Therefore, software used for safety critical systems should preserve high assurance properties. In order to comply with high assurance properties, a safety-critical system often shares resources between multiple concurrently active computing agents and must meet rigid real-time constraints. However, concurrency and timing constraints make the development of a safety-critical system much more error prone and arduous. The correctness of software systems nowadays depends mainly on the work of testing and debugging. Testing and debugging involve the process of de tecting, locating, analyzing, isolating, and correcting suspected faults using the runtime information of a system. However, testing and debugging are not sufficient to prove the correctness of a safety-critical system. In contrast, static analysis is supported by formalisms to specify the system precisely. Formal verification methods are then applied to prove the logical correctness of the system with respect to the specification. Formal verifica tion gives us greater confidence that safety-critical systems meet the desired assurance properties in order to avoid disastrous consequences.

Many networked computer systems are far too vulnerable to cyber attacks that can inhibit their functioning, corrupt important data, or expose private information. Not surprisingly, the field of cyber-based systems is a fertile ground where many tasks can be formulated as learning problems and approached in terms of machine learning algorithms.

This book contains original materials by leading researchers in the area and covers applications of different machine learning methods in the reliability, security, performance, and privacy issues of cyber space. It enables readers to discover what types of learning methods are at their disposal, summarizing the state-of-the-practice in this significant area, and giving a classification of existing work.

Those working in the field of cyber-based systems, including industrial managers, researchers, engineers, and graduate and senior undergraduate students will find this an indispensable guide in creating systems resistant to and tolerant of cyber attacks.

With the rapid growth of networking and high-computing power, the demand for large-scale and complex software systems has increased dramatically. Many of the software systems support or supplant human control of safety-critical systems such as flight control systems, space shuttle control systems, aircraft avionics control systems, robotics, patient monitoring systems, nuclear power plant control systems, and so on. Failure of safety-critical systems could result in great disasters and loss of human life. Therefore, software used for safety critical systems should preserve high assurance properties. In order to comply with high assurance properties, a safety-critical system often shares resources between multiple concurrently active computing agents and must meet rigid real-time constraints. However, concurrency and timing constraints make the development of a safety-critical system much more error prone and arduous. The correctness of software systems nowadays depends mainly on the work of testing and debugging. Testing and debugging involve the process of de tecting, locating, analyzing, isolating, and correcting suspected faults using the runtime information of a system. However, testing and debugging are not sufficient to prove the correctness of a safety-critical system. In contrast, static analysis is supported by formalisms to specify the system precisely. Formal verification methods are then applied to prove the logical correctness of the system with respect to the specification. Formal verifica tion gives us greater confidence that safety-critical systems meet the desired assurance properties in order to avoid disastrous consequences."

With the increasing availability of omics data and mounting evidence of the usefulness of computational approaches to tackle multi-level data problems in bioinformatics and biomedical research in this post-genomics era, computational biology has been playing an increasingly important role in paving the way as basis for patient-centric healthcare.Two such areas are: (i) implementing AI algorithms supported by biomedical data would deliver significant benefits/improvements towards the goals of precision medicine (ii) blockchain technology will enable medical doctors to securely and privately build personal healthcare records, and identify the right therapeutic treatments and predict the progression of the diseases.A follow-up in the publication of our book Computation Methods with Applications in Bioinformatics Analysis (2017), topics in this volume include: clinical bioinformatics, omics-based data analysis, Artificial Intelligence (AI), blockchain, big data analytics, drug discovery, RNA-seq analysis, tensor decomposition and Boolean network.

This compendium contains 10 chapters written by world renowned researchers with expertise in semantic computing, genome sequence analysis, biomolecular interaction, time-series microarray analysis, and machine learning algorithms.The salient feature of this book is that it highlights eight types of computational techniques to tackle different biomedical applications. These techniques include unsupervised learning algorithms, principal component analysis, fuzzy integral, graph-based ensemble clustering method, semantic analysis, interolog approach, molecular simulations and enzyme kinetics.The unique volume will be a useful reference material and an inspirational read for advanced undergraduate and graduate students, computer scientists, computational biologists, bioinformatics and biomedical professionals.

This important textbook introduces the concept of intrusion detection, discusses various approaches for intrusion detection systems (IDS), and presents the architecture and implementation of IDS. It emphasizes on the prediction and learning algorithms for intrusion detection and highlights techniques for intrusion detection of wired computer networks and wireless sensor networks. The performance comparison of various IDS via simulation will also be included.