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Since 9/11, the U.S. government and the private sector have devised
sophisticated ways of protecting people and assets. The threats
have evolved, however, becoming more insidious. They no longer
comprise just terrorists who target critical infrastructures. They
also include insider threats, such as PFC Manning and NSA
contractor Snowden who leaked classified defense information,
active shooter incidents like the Sandy Hook Elementary School
massacre, and the 2013 Boston Marathon terrorist bombing. These
events make it imperative for the public and private sectors to
engage in effective partnership to protect people, facilities, and
national infrastructure assets. Homeland Security and Private
Sector Business: Corporations' Role in Critical Infrastructure
Protection, Second Edition identifies the role the private sector
plays in securing our homeland and offers strategies to aid in the
fight against national and international threats. Addressing
mandates and legislation introduced since the first edition, this
new edition includes: Updates to the NIPP (National Infrastructure
Protection Plan) New case studies of both proper security policies
and procedures in practice versus costly security breaches Greater
focus on smaller business and practical "immediate use" guidance
New measures for assessing and addressing vulnerabilities and
threats New appendices with sample plans and practical checklists
Supplying tools that can easily be adapted and applied to every
business situation at all budget levels, the book helps businesses
counter the total threat, from traditional terrorists to inside
betrayers-providing a clear blueprint for securing people and
assets.
Since its initial publication in 1993, Development and Evaluation of Drugs from Laboratory through Licensure to Market has been used as a textbook and reference for scientists in biomedical research, industry, and regulatory agencies. Updated and expanded, this second edition examines recent advances in scientific and regulatory approaches as well as changes in the way in which drugs are discovered, developed, and evaluated. The information provided outlines critical steps beginning from drug discovery in the laboratory to licensure and approval for market.
Biomedical research is an intrinsically changing and evolving field. A more direct strategy for drug discovery has gradually replaced random screening of natural products. More rapid identification of key molecular structures for new drug candidates and characterization of biomolecules including proteins, polysaccharides, and nucleic acids are now possible. The ability to chemically modify cell surfaces and carbohydrate linkages has facilitated designs of the next generation of new drugs. Thoroughly discussing these issues and more, Development and Evaluation of Drugs from Laboratory through Licensure to Market, Second Edition focuses on the latest developments in the science and regulation of bringing new drugs to market, including activities of the International Commission on Harmonization.
Since 9/11, the U.S. government and the private sector have devised
sophisticated ways of protecting people and assets. The threats
have evolved, however, becoming more insidious. They no longer
comprise just terrorists who target critical infrastructures. They
also include insider threats, such as PFC Manning and NSA
contractor Snowden who leaked classified defense information,
active shooter incidents like the Sandy Hook Elementary School
massacre, and the 2013 Boston Marathon terrorist bombing. These
events make it imperative for the public and private sectors to
engage in effective partnership to protect people, facilities, and
national infrastructure assets. Homeland Security and Private
Sector Business: Corporations' Role in Critical Infrastructure
Protection, Second Edition identifies the role the private sector
plays in securing our homeland and offers strategies to aid in the
fight against national and international threats. Addressing
mandates and legislation introduced since the first edition, this
new edition includes: Updates to the NIPP (National Infrastructure
Protection Plan) New case studies of both proper security policies
and procedures in practice versus costly security breaches Greater
focus on smaller business and practical "immediate use" guidance
New measures for assessing and addressing vulnerabilities and
threats New appendices with sample plans and practical checklists
Supplying tools that can easily be adapted and applied to every
business situation at all budget levels, the book helps businesses
counter the total threat, from traditional terrorists to inside
betrayers-providing a clear blueprint for securing people and
assets.
The Lee family is composed of perhaps the most distinguished
ancestry on record, having provided, for example, greater numbers
of Revolutionary and Civil War generals and officers, politicians,
and statesmen than any family of comparable size and standing
The pharmaceutical industry is on the verge of an exciting and
challenging century. Advances in pharmaceutical sciences have
dramatically changed the processes of discovery and development of
new therapeutic drugs and, in turn, resulted in an extraordinary
increase in the potential prophylactic and therapeutic
interventions. In this atmosphere, an intimate understanding of the
mechanisms of pharmacokinetic and pharmacodynamic activity and the
processes of drug evaluation is essential.
Clinical Trials of Drugs and Biopharmaceuticals provides an
overview of current procedures and major issues involved in drug
and biopharmaceutical development. The book examines critical
biochemical and pharmaceutical considerations for trials conducted
during each phase of clinical development. It also reports
information related to early pre-clinical evaluations of
pharmacological activities and safety before proceeding with
initiation of clinical trials. The sections focus on clinical
assessments of drugs and biopharmaceuticals such as cardiovascular,
respiratory, central nervous system, gastrointestinal and liver,
genitourinary, skin, metabolism, and chemotherapeutic drugs as well
as vaccines, biotechnology-derived therapeutics, and plant-based
medicines.
Practical and informative, this step-by-step guide includes
information on all four phases of clinical trials prior to
licensure and covers the design of post-marketing studies. The
editors examine how recent advances and increased demand for safer
and more effective drugs have changed the process by which drugs
are developed and approved.
This is an EXACT reproduction of a book published before 1923. This
IS NOT an OCR'd book with strange characters, introduced
typographical errors, and jumbled words. This book may have
occasional imperfections such as missing or blurred pages, poor
pictures, errant marks, etc. that were either part of the original
artifact, or were introduced by the scanning process. We believe
this work is culturally important, and despite the imperfections,
have elected to bring it back into print as part of our continuing
commitment to the preservation of printed works worldwide. We
appreciate your understanding of the imperfections in the
preservation process, and hope you enjoy this valuable book.
If you are a semiconductor engineer or a magnetics physicist
developing magnetic memory, get the information you need with this,
the first book on magnetic memory. From magnetics to the
engineering design of memory, this practical book explains key
magnetic properties and how they are related to memory performance,
characterization methods of magnetic films, and tunneling
magnetoresistance effect devices. It also covers memory cell
options, array architecture, circuit models, and read-write
engineering issues. You'll understand the soft fail nature of
magnetic memory, which is very different from that of semiconductor
memory, as well as methods to deal with the issue. You'll also get
invaluable problem-solving insights from real-world memory case
studies. This is an essential book for semiconductor engineers who
need to understand magnetics, and for magnetics physicists who work
with MRAM. It is also a valuable reference for graduate students
working in electronic/magnetic device research.
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