This book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.

Nowadays there is an increasing emphasis on all aspects of adaptively gener ating a grid that evolves with the solution of a PDE. Another challenge is to develop efficient higher-order one-step integration methods which can handle very stiff equations and which allow us to accommodate a spatial grid in each time step without any specific difficulties. In this monograph a combination of both error-controlled grid refinement and one-step methods of Rosenbrock-type is presented. It is my intention to impart the beauty and complexity found in the theoretical investigation of the adaptive algorithm proposed here, in its realization and in solving non-trivial complex problems. I hope that this method will find many more interesting applications. Berlin-Dahlem, May 2000 Jens Lang Acknowledgements I have looked forward to writing this section since it is a pleasure for me to thank all friends who made this work possible and provided valuable input. I would like to express my gratitude to Peter Deuflhard for giving me the oppor tunity to work in the field of Scientific Computing. I have benefited immensly from his help to get the right perspectives, and from his continuous encourage ment and support over several years. He certainly will forgive me the use of Rosenbrock methods rather than extrapolation methods to integrate in time.

Water supply- and drainage systems and mixed water channel systems are networks whose high dynamic is determined and/or affected by consumer habits on drinking water on the one hand and by climate conditions, in particular rainfall, on the other hand. According to their size, water networks consist of hundreds or thousands of system elements. Moreover, different types of decisions (continuous and discrete) have to be taken in the water management. The networks have to be optimized in terms of topology and operation by targeting a variety of criteria. Criteria may for example be economic, social or ecological ones and may compete with each other. The development of complex model systems and their use for deriving optimal decisions in water management is taking place at a rapid pace. Simulation and optimization methods originating in Operations Research have been used for several decades; usually with very limited direct cooperation with applied mathematics. The research presented here aims at bridging this gap, thereby opening up space for synergies and innovation. It is directly applicable for relevant practical problems and has been carried out in cooperation with utility and dumping companies, infrastructure providers and planning offices. A close and direct connection to the practice of water management has been established by involving application-oriented know-how from the field of civil engineering. On the mathematical side all necessary disciplines were involved, including mixed-integer optimization, multi-objective and facility location optimization, numerics for cross-linked dynamic transportation systems and optimization as well as control of hybrid systems. Most of the presented research has been supported by the joint project "Discret-continuous optimization of dynamic water systems" of the federal ministry of education and research (BMBF).

Water supply- and drainage systems and mixed water channel systems are networks whose high dynamic is determined and/or affected by consumer habits on drinking water on the one hand and by climate conditions, in particular rainfall, on the other hand. According to their size, water networks consist of hundreds or thousands of system elements. Moreover, different types of decisions (continuous and discrete) have to be taken in the water management. The networks have to be optimized in terms of topology and operation by targeting a variety of criteria. Criteria may for example be economic, social or ecological ones and may compete with each other. The development of complex model systems and their use for deriving optimal decisions in water management is taking place at a rapid pace. Simulation and optimization methods originating in Operations Research have been used for several decades; usually with very limited direct cooperation with applied mathematics. The research presented here aims at bridging this gap, thereby opening up space for synergies and innovation. It is directly applicable for relevant practical problems and has been carried out in cooperation with utility and dumping companies, infrastructure providers and planning offices. A close and direct connection to the practice of water management has been established by involving application-oriented know-how from the field of civil engineering. On the mathematical side all necessary disciplines were involved, including mixed-integer optimization, multi-objective and facility location optimization, numerics for cross-linked dynamic transportation systems and optimization as well as control of hybrid systems. Most of the presented research has been supported by the joint project "Discret-continuous optimization of dynamic water systems" of the federal ministry of education and research (BMBF).

Nowadays there is an increasing emphasis on all aspects of adaptively gener ating a grid that evolves with the solution of a PDE. Another challenge is to develop efficient higher-order one-step integration methods which can handle very stiff equations and which allow us to accommodate a spatial grid in each time step without any specific difficulties. In this monograph a combination of both error-controlled grid refinement and one-step methods of Rosenbrock-type is presented. It is my intention to impart the beauty and complexity found in the theoretical investigation of the adaptive algorithm proposed here, in its realization and in solving non-trivial complex problems. I hope that this method will find many more interesting applications. Berlin-Dahlem, May 2000 Jens Lang Acknowledgements I have looked forward to writing this section since it is a pleasure for me to thank all friends who made this work possible and provided valuable input. I would like to express my gratitude to Peter Deuflhard for giving me the oppor tunity to work in the field of Scientific Computing. I have benefited immensly from his help to get the right perspectives, and from his continuous encourage ment and support over several years. He certainly will forgive me the use of Rosenbrock methods rather than extrapolation methods to integrate in time."

Envy is a vicious and shameful response to the good fortune of others, one that ruins friendships and plagues societies-or so the common thinking goes, shaped by millennia of religious and cultural condemnation. Envy's bad reputation is not completely unwarranted; envy can indeed motivate malicious and counterproductive behavior and may strain or even tear apart relations between people. However, that is not always the case. Investigating the complex nature of this emotion reveals that it plays important functions in social hierarchies and it can motivate one to self-improve and even to achieve moral virtue. Philosophers and psychologists in this volume explore envy's characteristics in different cultures, spanning from small hunter-gatherer communities to large industrialized countries, and contexts as diverse as academia, marketing, artificial intelligence, and Buddhism. They explore envy's role in both the personal and the political sphere, showing the many ways in which envy can either contribute or detract to our flourishing as individuals and as citizens of modern democracies.