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Millions of people each year decide to participate in clinical
trials--medical research studies involving an innovative treatment
for a medical problem. For the patient, such participation can
sometimes be a life-saving choice. But it can also be just the
opposite. Our country years ago adopted rules designed to assure
that people are making informed choices about participation. This
book explains the reality behind those rules: that our current
system of clinical trials hides much of the information patients
need to make the right choices.
Witness the following scenarios:
-Hundreds of patients with colon cancer undergo a new form of
keyhole surgery at leading cancer centers--never being told that
85% of colorectal surgeons, worried that it increases the risk of
the cancer returning, would not themselves undergo that
procedure.
-Tens of thousands of women at high risk of developing breast
cancer are asked to participate in a major research study. They are
told about the option of having both breasts surgically
removed--but not told about the option of taking a standard
osteoporosis pill that might cut the risk of getting breast cancer
by one-half or more.
What The Doctor Didn't Say, principally written by a nationally
prominent expert, is the first book to reveal many heretofore
hidden aspects about the true nature of participation in clinical
trials. It shows why options not commonly known--including getting
a new treatment outside of a research study--can often be the best
choice. It explains how patients can make good decisions even if
there is only limited information about a treatment's effect. And
it does this through the eye-opening stories of what is
happeningdaily to thousands of people.
This book ends up confronting the fundamental dilemma of medical
research: Participation in clinical trials plays a vital role in
advancing knowledge, and many experts fear that if the information
provided herein became widely known, fewer people would
participate. But the authors demonstrate that there is no need to
deceive people into participating in research. We can have a system
that promotes participation while still providing truthful
information to participants.
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