explains in detail how extracellular vesicles are produced, endocytosed, and the mechanisms by which molecules play biological roles in the treatment of various diseases.

Volume Two of this two-volume sequence presents a comprehensive overview of protein structure prediction methods and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.

Volume One of this two-volume sequence focuses on the basic characterization of known protein structures, and structure prediction from protein sequence information. Eleven chapters survey of the field, covering key topics in modeling, force fields, classification, computational methods, and structure prediction. Each chapter is a self contained review covering definition of the problem and historical perspective; mathematical formulation; computational methods and algorithms; performance results; existing software; strengths, pitfalls, challenges, and future research.

Volume One of this two-volume sequence focuses on the basic characterization of known protein structures, and structure prediction from protein sequence information. Eleven chapters survey of the field, covering key topics in modeling, force fields, classification, computational methods, and structure prediction. Each chapter is a self contained review covering definition of the problem and historical perspective; mathematical formulation; computational methods and algorithms; performance results; existing software; strengths, pitfalls, challenges, and future research.

Volume Two of this two-volume sequence presents a comprehensive overview of protein structure prediction methods and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.

In this book we design some high-performance and low-complexity filter banks for multimedia compression and digital communications. We first present a systematic design of the fast approximation of the Discrete Cosine Transform (DCT) using the lifting scheme. A family of fast lapped transforms is then developed, using time-domain pre- and post-processing of the DCT. Compared to the wavelet-based JPEG 2000 standard, our method achieves similar performance with lower complexity. It has been applied into Microsoft/SMPTE VC-1 and JPEG XR standards. Several generalizations are developed next. First, we propose a general structure for linear-phase paraunitary filter banks that employs multiple stages of pre- and post-processing of the DCT. Secondly, we investigate the optimal pre- and post-processing for wavelet-based image and video compression. We then introduce an efficient structure for oversampled linear-phase filter banks. Finally, the application of oversampled filter bank in channel equalization is investigated, and a modified Orthogonal Frequency Division Multiplexing (OFDM) scheme is proposed.

Nanomaterials, with their unique size-dependent physical and chemical properties, have shown promising advantages as drug and gene delivery vehicles, ultra-sensitive intracellular detectors and novel therapeutic drugs. Nanopharmaceutics is one of the disciplines that will benefit the most from this technology.Nanotechnology will have a revolutionary impact on cancer diagnosis and therapy due to the exceptional characteristics of nanopharmaceutics.This book provides an overview of some tools, methods, and materials of nanotechnology that offer potential applications in pharmaceutics, followed by a series of examples showing applications that are already in development. It may very well inspire researchers to develop a new generation of pharmaceutics with inventive non-traditional approach and employ nanoscale science for the benefit of the patient.