This book provides a systematic introduction to the observation and application of kinetic Alfven waves (KAWs) in various plasma environments, with a special focus on the solar-terrestrial coupling system. Alfven waves are low-frequency and long-wavelength fluctuations that pervade laboratory, space and cosmic plasmas. KAWs are dispersive Alfven waves with a short wavelength comparable to particle kinematic scales and hence can play important roles in the energization and transport of plasma particles, the formation of fine magneto-plasma structures, and the dissipation of turbulent Alfven waves. Since the 1990s, experimental studies on KAWs in laboratory and space plasmas have significantly advanced our understanding of KAWs, making them an increasingly interesting subject. Without a doubt, the solar-terrestrial coupling system provides us with a unique natural laboratory for the comprehensive study of KAWs. This book presents extensive observations of KAWs in solar and heliospheric plasmas, as well as numerous applications of KAWs in the solar-terrestrial coupling system, including solar atmosphere heating, solarwind turbulence, solar wind-magnetosphere interactions, and magnetosphere-ionosphere coupling. In addition, for the sake of consistency, the book includes the basic theories and physical properties of KAWs, as well as their experimental demonstrations in laboratory plasmas. In closing, it discusses possible applications of KAWs to other astrophysical plasmas. Accordingly, the book covers all the major aspects of KAWs in a coherent manner that will appeal to advanced graduate students and researchers whose work involves laboratory, space and astrophysical plasmas.

A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine's most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule's structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.

This book provides a systematic introduction to the observation and application of kinetic Alfven waves (KAWs) in various plasma environments, with a special focus on the solar-terrestrial coupling system. Alfven waves are low-frequency and long-wavelength fluctuations that pervade laboratory, space and cosmic plasmas. KAWs are dispersive Alfven waves with a short wavelength comparable to particle kinematic scales and hence can play important roles in the energization and transport of plasma particles, the formation of fine magneto-plasma structures, and the dissipation of turbulent Alfven waves. Since the 1990s, experimental studies on KAWs in laboratory and space plasmas have significantly advanced our understanding of KAWs, making them an increasingly interesting subject. Without a doubt, the solar-terrestrial coupling system provides us with a unique natural laboratory for the comprehensive study of KAWs. This book presents extensive observations of KAWs in solar and heliospheric plasmas, as well as numerous applications of KAWs in the solar-terrestrial coupling system, including solar atmosphere heating, solarwind turbulence, solar wind-magnetosphere interactions, and magnetosphere-ionosphere coupling. In addition, for the sake of consistency, the book includes the basic theories and physical properties of KAWs, as well as their experimental demonstrations in laboratory plasmas. In closing, it discusses possible applications of KAWs to other astrophysical plasmas. Accordingly, the book covers all the major aspects of KAWs in a coherent manner that will appeal to advanced graduate students and researchers whose work involves laboratory, space and astrophysical plasmas.